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替比夫定治疗恶性肿瘤并发慢性乙型肝炎30例疗效观察

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摘要 慢性乙型肝炎系HBV持续感染引起的肝脏慢性炎症坏死性疾病。在恶性肿瘤和慢乙肝并存时,患者应用细胞毒性药物化疗或肾上腺皮质激素,以及放射治疗可使机体免疫防御、自稳功能失调,耐受状态被打破,HBV大量复制,诱发一系列级联反应,在促炎分子的作用下,导致机体损伤,使得肝炎急性加剧、甚至发生肝衰竭。本组根据中华医学会《慢性乙型肝炎防治指南》,对恶性肿瘤合并乙型肝炎的患者接受放化疗前给予替比夫定600mg/d治疗,并观察疗效。
作者 张庆
出处 《陕西医学杂志》 CAS 2013年第9期1254-1255,共2页 Shaanxi Medical Journal
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