中国汉族人群Mn-SOD基因V(16)A多态性与运动能力的关联研究

Research on the Association between the Mn-SOD Gene V(16) A Polymorphism and Athletic Ability in people of Han Nationality in China

目的:探讨Mn-SOD基因V(16)A多态性与运动能力的关联,为运动员早期科学选材提供基因标记。方法:应用PCR-RFLP方法对35名中国汉族赛艇、皮划艇有氧项目运动员进行基因分型;同时测试他们的体成分、最大摄氧量、通气无氧阈以及心率变异性(HRV)频域相关参数指标。结果:在男子运动员中,携A等位基因者去脂体重显著高于VV基因型者,而VV基因型者最大摄氧量相对值显著高于(VA+AA)型者;在女子运动员中,携VV基因型者脂肪百分比、身体脂肪量和身体质量指数均显著高于携A等位基因者。结论:Mn-SOD基因V(16)A多态性与中国汉族赛艇、皮划艇有氧项目运动员部分运动能力指标有关联,但能否作为运动员选材用分子生物学标记,还需加大样本量进一步验证。

Objective： To explore the association between Mn-SOD gene V（16） A polymorphism and exercise capacity,in order to screen genetic markers of athletes early scientific selection.Methods： By adopting the method of PCR-RFLP to discuss the genotyping of 35 Han Chinese rowing,canoeing aerobic athletes,meanwhile testing their body composition,the related indexes of maximal aerobic capacity,physiological parameters and heart rate variability（HRV）.Results： In the male athletes,Lean body mass was significantly higher in the A allele carriers compared to VV genotype carriers,Relative VO2max was very significantly greater in VV genotype carriers compared to A allele carriers.In the female athletes,fat percentage,body fat and body mass index were significantly higher in VV genotype carriers compared to A allele carriers.Conclusion： Mn-SOD gene V（16） A polymorphism was associated with part related indicators of athletic ability in rowing,canoeing aerobic athletes of Han nationality in China,but can be used as molecular biological markers of athletes selecting,it still need to further verification by increasing the sample size.