肺炎支原体抗体阳性儿童的锌和维生素D含量分析

Zinc and vitamin D content in children positive for Mycoplasma pneumoniae

目的分析肺炎支原体抗体阳性的儿童锌和维生素D含量。方法分别用酶联免疫法检测肺炎支原体抗体(MP),原子吸收光谱法检测锌含量,电化学发光免疫分析法检测25-羟基维生素D含量,用u检验统计分析阳性组与对照组的锌、25-羟基维生素D含量,用χ2检验统计分析两组的锌和维生素D缺乏率的差异。结果对照组锌和25-羟基维生素D含量分别为(75.33±16.03)μmol/L、(27.08±13.76)ng/ml,缺乏率为17.85%、8.57%;阳性组锌和25-羟基维生素D含量分别为(65.06±17.11)μmol/L、(26.64±12.82)ng/ml,缺乏率为35.71%、15.71%,两组的锌含量(u=5.185,P<0.05)和缺乏率都有显著差异(χ2=11.38,P<0.05),25-羟基维生素D含量(u=0.276,P>0.05)和缺乏率无差异(χ2=3.35,P>0.05)。结论肺炎支原体抗体阳性患儿及时补充锌对提高疗效、缩短病程有重要意义。

Objective To investigate the levels of zinc and vitamin D in children positive for Mycoplasma pneumoniae. Methods ELISA method was used to detect Mycoplasmapneumoniae antibody（MP）. The zinc content was detected using atomic absorption spectrometry. The serum 25-hydroxy vitamin D level was analyzed using immunoassay. The differences of zinc and 25-hydroxy vitamin D levels as well as the proportions of zinc and 25-hydroxy vitamin D deficiency were compared between the two groups. Results The zinc level （65.06 ± 17.11umol/L）in children positive for Mycoplasma pneumoniae was significantly lower than the control group（75.33 ± 16.03umol/L,u=5.185 ,P〈0.05）. The serum level of 25-hydroxy vitamin D showed no significant differences between the two groups （P〉0.05）. The rate of zinc deficiencies in children positive for Mycoplasma pneumoniae （135.71%）was higher than the control group （17.85%, X^2=11.3,P〈0.05）. There was no significant differences in the rate of 25-hydroxy vitamin D deficiencies between the two groups （P〉0.05）. Conclusions Zinc supplements can improve curative effect and shorten duration of hospitalization of children positive for Mycoplasma pneumoniae.