丹参对庆大霉素耳蜗毒性的防护作用

Preventive effect of Radix Salvia Miltiorrhizae on gentamicin ototoxicity

目的 探讨丹参对庆大霉素耳蜗毒性的防护作用。方法 择蒙古沙鼠 30只 ,随机分为 3组 :①庆大霉素组 (GM组 ) ;②庆大霉素 +丹参保护组 (GD组 ) ;③对照组 (NS组 ) ,每组 10只。GM组和GD组臀部肌肉注射庆大霉素 150mg/kg/d ,GD组同时注射丹参1g/kg/d ,对照组注射生理盐水 1ml/d ,连续用药 14d后观察耳蜗的形态和功能。 结果 GM组耳蜗功能和结构损害严重 ,GD组耳蜗功能和结构损伤较轻 ,耳蜗复合动作电位 (CAP)反应阈和毛细胞损伤率两组比较有显著性差异 ( P <0 .0 1)。结论 结果表明丹参对庆大霉素的耳毒性可能有防护作用。

Objective To explore the reduction of gentamicin ototoxicity with Radix Salvia Miltiorrhizae. Methods Thirty Mongolia gerbles were divided into 3 groups, 10 in each group. Group 1 was treated with gentamicin alone, Group 2 was treated with gentamicin and Radix Salvia Miltiorrhizae, and Group 3 was the control. Gentamicin(150 mg/kg/d) and Radix Salvia Miltiorrhizae(1 g/kg/d) were given via intramuscular injection, respectively, for 14 days continuously. Morphological and functional observation of the cochlea was performed. Results Changes of complex action potential (CAP) and the cochlear structure were obvious in Group 1, but only slight changes were found in Group 2. There was a significant difference in CAP response threshold and the cochlear hair cell loss ratio between Group 1 and Group 2 (P< 0.01 ). Conclusion Radix Salvia Miltiorrhizae may reduce gentamicin ototoxicity.