宫颈微腺体增生-易于误认为恶性肿瘤的良性病变

Microglandular hyperplasia ,a benign lesion that can be misinterpreted as malignancy

目的 加强对宫颈微腺体增生的认识。方法 报告 5例宫颈微腺体增生 ,其中包括 2例不典型宫颈微腺体增生 ,并进行了特殊染色及免疫组化标记。结果 患者平均年龄 44岁 ,其中 1例有口服避孕药史。通过分析本文概括了该病变典型与不典型的组织学特征 :密集集合的大小不等的腺体、部分区呈网状或实性的图象、间质或腺腔中炎细胞的浸润、可出现上皮的多形性及核深染但无核分裂或核分裂偶见 (≤ 1 /1 0HPF) ;强调了可能与恶性肿瘤相混淆的不典型宫颈微腺体增生的诊断与鉴别诊断要点 ;分析了特殊染色PAS、AlcianBlue及免疫酶标CEA单抗、P5 3、Ki 6 7在诊断与鉴别诊断中的意义。结论 宫颈微腺体增生是一种完全良性病变 。

Objective Tohighlightmicroglandularhyperplasia (MGH)ofthecervixtoavoidthispitfallofmisdiagnosis . Methods Histopathologicalanalysis,specialstainingandimmunohistochemistrywereusedin 5casesofMGHofthecervix ,with atypicalhyperplasiain 2cases. Results Theaverageageofthepatientswas44 ,andoneofthemhadahistoryofovalcontra ceptiveuse .Typicalandunusualhistologicalfeaturesofthediseaseincludedtightlypackedglandsindifferentsizesandshapes, presentationofinflammatorycellsinstromaandglandularlumens,andfocalepithelialcellpleomorphismandhyperchromatismbut withoutmitosis.ThedifferentialdiagnosisofatypicalMGHwasdiscussed ,inwhichspecialstainingofPAS ,diastase -PAS ,Al cianblueandimmunohistochemicalstainsforCEA ,p5 3andKi- 6 7wereveryhelpful. Conclusion Itisextremelyimportant torecognizethatMGHisanentirelybenignlesion .