醋酸泼尼松龙对髁突软骨急性损伤后修复的影响

The effect of prednisolone on the regeneration of condylar cartilage of the rabbit

目的 研究局部应用糖皮质激素类药物对髁突软骨损伤后修复再生的影响。 方法选用成年雄性大白兔 37只 ,分成 4组。第 1组 :髁突软骨全层损伤后局部应用醋酸泼尼松龙组 ;在兔髁突的前斜面形成直径 2mm的软骨全层缺损 ,局部应用醋酸泼尼松龙 2 5mg。第 2组 :单纯髁突软骨全层损伤组。第 3组 :空白手术对照组。第 4组 :正常对照组。结果 第 1组动物的髁突软骨损伤区骨皮质断端进行性增生 ,术后 12周时 ,原损伤区几乎充满致密骨质 ,表面有纤维组织覆盖。

Objective To investigate the effect of the prednisolone on the condylar cartilage regeneration. Methods A full thickness defect without penetrating the subchondral compact bone was made in the condylar cartilage of the adult rabbits, and prednisolone(25 mg) was applied locally. The reparative tissue was observed histologically and histochemically. Results The compact bone in the area of the defect of the condylar cartilage showed hyperplasia, and the defect was filled with compact bone at the end of twelve weeks. Conclusions Prednisolone is able to repair the defect of the condylar cartilage.