布地奈德雾化吸入治疗新生儿肺炎63例

Clinical Efficacy and Safety of Budesonide Aerosol Inhalation in Treating Neonatal Pneumonia in 63 Cases

目的探讨布地奈德雾化吸入治疗新生儿肺炎的临床治疗效果及安全性。方法选择医院新生儿肺炎患者126例,随机分为观察组和对照组。在西医常规治疗基础上,对照组给予0.9%氯化钠注射液雾化吸入,观察组给予布地奈德雾化吸入,观察两组的临床治疗效果及安全性。结果观察组总有效率为95.24%,明显高于对照组的82.54%(P<0.05)。观察组患儿鼻阻消失时间、呼吸困难好转时间及肺部罗音消失时间均短于对照组(P<0.05)。不良反应发生率观察组为6.35%,对照组为4.76%,两组比较差异无统计学意义(P>0.05)。结论在新生儿肺炎的治疗中采用雾化吸入布地奈德辅助西医常规治疗的疗效肯定,应用安全。

Objective To discuss the clinical efficacy and safety of budesonide inhalation in the treatment of neonatal pneumonia. Methods 126 patients with neonatal pneumonia in our hospital were selected and randomly divided into the observation group and the control group. On the basis of conventional western treatment, the control group was inhaled 0. 9% normal saline injection, while the ob- servation group was inhaled budesonide. The clinical efficacy and safety were observed in the two groups. Results The total effective rate was 95.24% in the observation group and 82.54% in the control group, the difference between them had statistical significance （P 〈 0.05）. The rhinostegnosis disappearance time, improvement time of difficulty breathing, disappearance time of lung tales in the ob- servation group were shorter than those in the control group, the difference between them had statistically significant（ P 〈0. 05）. The rate of adverse reactions was 6.35% in the observation group and 4.76% in the control group, the difference between them had no statisti- cal significance（ P 〉 0.05）. Conclusion Adopting the atomization inhalation of budesonide as the assisting treatment of conventional western treatment in treating neonatal pneumpnia has definite effect with application security.