基质金属蛋白酶及Ⅳ型胶原在胃癌中的表达及其意义

Expression and significance of MMP_2 and type Ⅳ collagen in gastric cancer

目的 探讨基质金属蛋白酶 (MMP2 )及Ⅳ型胶原与胃癌浸润转移的关系。 方法 对2 7例胃癌患者采用临床观察及免疫组化方法观察MMP2 及Ⅳ型胶原在癌组织中的表达。 结果 MMP2 在低分化腺癌、管状腺癌的癌细胞和癌间质中表达率分别为 85 7%、77 7% ,同时有Ⅳ型胶原的破坏 ;在血管淋巴管癌栓及淋巴结转移癌病例中表达率分别为 83 3%、86 7%。 结论 MMP2 的高表达与胃癌浸润和转移有关 ,主要是破坏细胞外间质 ,尤其是Ⅳ型胶原。MMP2

Objective To evaluate the relationship between the expression of MMP 2, type Ⅳ callagen, and invasion and metastasis of gastric cancer. MothodsThe expression of MMP 2 and Type Ⅳ collagen was observed by using immunohistochemistry technique. ResultsThe MMP 2 expression clearly appeared in the poor differentiated adenocarcinoma and tubular adenocarcinoma(85 7%,77 7%). Type Ⅳcollagen destruction was observed simultaneously. MMP 2 was highly expressed in patients with cancer embolus in blood vessel and lymphatic vessel or with lymph node metastasis (83 3%,86 7%). Conclutions The high expression of MMP 2 was signi ficantly associated with infiltration and metastasis of gartric cancer. The extracellular matrix, especially type Ⅳ collagen was destructed in the cases of high expression of MMP 2. These rusults suggest that monitoring the level of MMP 2 expression may be an index for evaluation of prognosis.