无创正压通气联合纳洛酮治疗慢性阻塞性肺疾病合并肺性脑病

Effect of noninvasive positive pressure ventilation combined with naloxone in treatment of chronic obstructive pulmonary disease complicated pulmonary encephalopathy

目的探讨无创正压通气联合纳洛酮治疗慢性阻塞性肺疾病(COPD)的临床治疗效果。方法选取2010-06—2013-01我院收治的60例慢性阻塞性肺疾病合并肺性脑病患者,根据用药的不同随机分成治疗组和对照组进行治疗,每组均30例。治疗组常规用药及BIPAP联合纳洛酮治疗,对照组常规治疗及BIPAP治疗,观察2组患者的意识恢复情况、动脉血气变化、气管插管率、治疗有效率、住院时间等指标。结果 2组治疗后意识恢复情况、动脉血气分析指标、气管插管率以及临床治疗有效率、住院时间等各项情况对比差异有统计学意义(P<0.05)。结论 BIPAP联合纳洛酮治疗COPD合并肺性脑病可较快改善患者的临床症状,提高与患者的人机同步率。

Objective To explore the clinical effect of noninvasive positive pressure ventilation combined with naloxone in the treatment of chronic obstructive pulmonary disease（COPD） complicated pulmonary encephalopathy.Methods From June 2010 to January 2013,60 patients with chronic obstructive pulmonary disease combined with pulmonary encephalopathy in our hospital were treated,which were randomly divided into treatment group and control group according to different medications;patients in each group were 30 cases.The treatment group received regular medication and BIPAP combined naloxone treatment,control group received conventional treatment and BIPAP treatment.The consciousness recovery,arterial blood gas,endotracheal intubation rate,efficiency of treatment,hospitalization and other indicators in these patients were observed.Results After treatment,the recovery of consciousness,arterial blood gas analysis,endotracheal intubation rate and clinical efficiency,hospitalization time and other circumstances in the groups were compared,and there were significant statistical differences（P0.05）.Conclusion BIPAP combine naloxone in the treatment of COPD complicated pulmonary encephalopathy can improve the curative rate,and increase the patient＇s ventilator synchrony rate.