摘要
目的 观察维拉帕米对利多卡因致小鼠惊厥作用的影响.方法 将昆明种小鼠随机分为3组（n=10）：生理盐水（NS）组、维拉帕米1.5 mg·kg^-1（V1.5）组、3.0 mg·kg^-1（V3.0）组.以NS或不同剂量的维拉帕米给小鼠腹腔注射,5 min后,各组腹腔注射致惊厥剂量的利多卡因,观察各组小鼠发生惊厥的只数、已发生惊厥小鼠的惊厥潜伏期、持续时间、惊厥次数及惊厥级数.结果 与NS组相比,V3.0组惊厥潜伏期延长（P〈0.05）;V1.5、V3.0组惊厥持续时间缩短（P〈0.05）;V3.0组惊厥次数减少（P〈0.05）;维拉帕米使利多卡因致小鼠惊厥的级数降低.结论 维拉帕米能部分拮抗利多卡因致小鼠惊厥作用.
Objective To observe the influence of verapamil on lidocaine - induced convulsion in mice. Methods 30 mice were randomly divided into 3 groups （n = 10 each） ： normal saline （NS） group, verapamil 1.5 mg·kg^-1 Vl5 ） and 3.0 mg·kg^-1（ V30 ） groups. Convulsant dose of lodocaine was administered intraperitoneally 5 rain after NS or different doses of verapamil had been administered intraperitoneally. The number, latency and duration of convulsive mice, convulsion times and convulsion level were observed. Results Compared with NS group, the latency of convlsive mice in V3.0 group extended siginicantly （P 〈 0.05 ） ; the duration of convulsive mice in Vj.5 and V3.0 group reduced sig-nificantly （P 〈 0.05 ） ; convulsion times in V30 group decreased siginificantly （P 〈 0.05 ）. Concusion Verapamil can antagonize lidocaine-induced convulsion in mice.
出处
《徐州医学院学报》
CAS
2013年第8期505-507,共3页
Acta Academiae Medicinae Xuzhou
基金
江苏省高校自然科学基础研究项目（07KJD310219）
