丁苯酞对癫痫小鼠脑内氨基酸的影响

The influence of butylphthalide on amino acid in epileptic mice's brain

目的观察丁苯酞对癫痫小鼠脑内氨基酸含量的影响。方法小鼠腹腔注射丁苯酞溶液30 min后制作急性癫痫模型,对癫痫小鼠脑内的4种氨基酸(天冬氨酸、γ-氨基丁酸、谷氨酸、甘氨酸)的含量变化进行观察。结果丁苯酞能降低兴奋性氨基酸谷氨酸的含量,并能降低Glu/GABA的比值(模型组38.78;丁苯酞高剂量组5.52),与模型组比较差异均有统计学意义(P<0.05)。结论丁苯酞可以调节大脑中兴奋/抑制系统的平衡,从而可能缓解癫痫的发作。

Objective Aim to investigate the influence of butylphthalide （NBP） on amino acid content in epileptic mice＇s brain. Methods NBP was intraperitoneally injected （ip） mice and acute epileptic mice models were made after 30 min. The change of the four amino acid（ aspartic acid, gamma-aminobutyric acid, glutamate, glycine） content in brain of epileptic mice was investigated. Results For NBP treated epileptic mice, when compared with model group, the contents of glutamate and glutamate/ gamma-aminobutyric acid（ model group ： 38.78 ; NBP higc dose group ： 5.52 ） were reduced （ P 〈 0.05 ） in brain of epileptic mice. Conclusion NBP could regulate the balance of excitement and inhibition systems which might relieve seizures.