益气扶正法治疗脓毒症30例临床观察及其对炎症反应的影响

Clinical Efficacy of Benefiting Qi for Strengthening Resistance on Sepsis and Inflammatory Reaction:A Clinical Observation of 30 Cases

目的:观察益气扶正中药制剂黄芪注射液对脓毒症的临床疗效以及对血清炎症因子水平的影响。方法:将30例脓毒症患者随机分为治疗组和对照组各30例,治疗组采用西医常规治疗加黄芪注射液治疗;对照组采用西医常规治疗,疗程7 d,分别比较治疗前后中医症状积分、APACHEⅡ评分以及外周静脉血IL-6、IL-10、CRP、PCT等水平的变化。结果:治疗后2组中医疗效比较,差异有统计学意义(P<0.05);两组患者治疗前后气虚症状积分比较,差异有统计学意义(P<0.05);治疗后2组患者的IL-6和CRP水平均降低(P<0.05),治疗组优于对照组,差异有统计学意义(P<0.05)。结论:益气扶正法能提高脓毒症患者的中医临床疗效,可调节IL-6和CRP水平,抑制过度炎症反应。

Objective： To observe the clinical efficacy of Benefiting Qi for Strengthening Resistance in the treatment of sepsis and effect on serum inflammatory factor levels.Methods： Sixty cases of sepsis patients were randomly divided into treatment and control groups,30 cases in each group.Patients were treated with conventional western medical treatment plus Astragalus injection in treatment group and conventional western medicine treatment in control group,with the course of 7 days.TCM symptoms score,APACHE Ⅱ score,as well as peripheral blood IL-6,IL-10,CRP and PCT levels in the two groups were compared before and after treatment.Results： Differences of TCM therapeutic effect is statistically significant between two groups（P 0.05）.Differences of Qi deficiency symptoms score are statistically significant between two groups before and after treatment（P0.05）.Serum level of IL-6 and CRP decreased in the two groups after treatment（P0.05）,and the treatment group was better than the control group,Differences are statistically significant（P 0.05）.Conclusion： Benefiting Qi for Strengthening Resistance can improve the clinical efficacy of sepsis,regulate IL-6 and CRP levels and inhibit excessive inflammatory response.