血清胰淀素、ADMA水平与代谢综合征的相关性

Correlation among serum levels of amylin,ADMA and metabolic syndrome

测定代谢综合征（MS）患者血清胰淀素和非对称二甲醛精氨酸（ADMA）水平,探讨两者的相关性及二者对MS的影响。方法：70例患者和体检对象根据其存在MS组分的个数分为非MS组（MS组分0~1个,20例）、MS高危组（MS组分2个,23例）和MS组（MS组分〉2个,27例）。分别测定空腹血糖、血脂、胰岛素、腰臀比（WHR）、体重指数（BMI）等指标,同时测定血清胰淀素、ADMA的水平。结果：与非MS组比较,MS高危组,MS组血清胰淀素[（0.41±0.04）g/L比（0.46±0.06）g/L比（0.49±0.06）g/L]、ADMA[（1.28±0.06）μg/L比（1.46±0.07）μg/L比（1.51±0.08）μg/L]的水平明显升高（P〈0.05）,且MS组明显高于MS高危组（P均〈0.05）。Pearson相关分析表明,血清胰淀素与甘油三酯（TG）、空腹胰岛素（FINS）、BMI、WHR、胰岛素抵抗指数（IRI）、ADMA呈正相关性（r=0.441~0.563,P均〈0.05）;与高密度脂蛋白胆固醇（HDL-C）呈负相关（r=-0.461,P〈0.05）;ADMA与IRI、BMI、FINS呈正相关（r=0.445~0.483,P〈0.05）。Logistic回归分析显示胰淀素、BMI、ADMA、IRI是MS的独立危险因素（OR=5.573~7.169,P均〈0.05）。结论：血清胰淀素和非对称二甲醛精氨酸的表达与代谢综合征的发生有关,两者都是MS的独立危险因素。

Objective：To examine levels of serum amylin and asymmetric dimethylarginine（ADMA）in patients with metabolic syndrome（MS）,explore their correlation related with MS.Methods：According to number of MS components,a total of 70subjects were divided into non-MS group（MS components 0-1,n=20）,MS high risk group（MS components 2,n=23）and MS group（MS components＆gt;2,n=27）.Fasting plasma glucose,blood lipid,insulin,waist hip ratio（WHR）,body mass index（BMI）,serum levels of amylin and ADMA were measured.Results： Compared with non-MS group,there were significant increase in serum levels of amylin[（0.41±0.04）g/L vs.（0.46±0.06）g/L vs.（0.49±0.06）g/L]and ADMA[（1.28±0.06）μg/L vs.（1.46±0.07）μg/L vs.（1.51± 0.08）μg/L]in MS high risk group and MS group,P＆lt;0.05,and those of MS group were significantly higher than those of MS high risk group,P＆lt;0.05both.Pearson correlation analysis indicated that serum amylin was positively correlated with triglyceride（TG）,fasting insulin（FINS）,BMI,WHR,insulin resistance index（IRI）and ADMA（r=0.441~0.563,P＆lt;0.05all）;and negatively correlated with high density lipoprotein cholesterol（HDL-C）（r =-0.461,P＆lt;0.05）;ADMA was positively correlated with IRI,BMI and FINS（r=0.445~0.483,P＆lt;0.05）.Logistic regression analysis indicated that amylin,BMI,ADMA and IRI were independent risk factors of MS（OR= 5.573~7.169,P＆lt;0.05all）.Conclusion：Levels of serum amylin and asymmetric dimethylarginine are related to occurrence of metabolic syndrome,both of them may be independent risk factors of MS.