老年原发性高血压患者血压晨峰现象与靶器官损害的相关性研究

Correlation between morning blood pressure surge and target organ damage in aged patients with essential hypertension

目的:探讨老年原发性高血压患者血压晨峰(MBPS)与靶器官损害的相关性。方法:老年原发性高血压患者292例,据24h动态血压分晨峰组(MBPS组,128例)与非晨峰组(非MBPS组,164例),检查血脂、空腹血糖、肌酐,计算人体质量指数(BMI)、行心脏和颈动脉超声检查,计算左室质量指数(LVMI)、颈动脉内膜中层厚度(IMT)。结果:与非MBPS组比较,MBPS组24h收缩压(SBP)[(138.2±13.2)mmHg比(153.1±12.1)mmHg]、白昼SBP[(143.3±12.7)mmHg比(158.2±9.1)mmHg]以及夜间SBP[(136.6±9.4)mmHg比(150.7±10.1)mmHg]均明显升高(P<0.05),LVMI[(101.76±34.45)g/m2比(138.13±37.6)g/m2]、颈动脉IMT[(0.84±0.11)mm比(1.35±0.35)mm]均明显增大(P<0.05);Pearson相关分析显示,血压晨峰与LVMI、IMT呈正相关(r分别=0.688,0.524,P均<0.05)。结论:老年原发性高血压患者血压晨峰现象加重靶器官损害。

Objective：To explore the correlation between morning blood pressure surge（MBPS）and target organ damage（TOD）in aged patients with essential hypertension（EH）.Methods：According to 24hambulatory blood pressure,a total of 292aged EH patients were divided into MBPS group（n=128）and non-MBPS group（n=164）.Blood lipids,fasting blood glucose,creatinine were measured and body mass index（BMI）was calculated.Heart and carotid ultrasonography were performed,and left ventricular mass index（LVMI）and carotid intima-media thickness（IMT）were calculated.Results：Compared with non-MBPS group,there were significant increase in 24hsystolic blood pressure（SBP）[（138.2±13.2）mmHg vs.（153.1±12.1）mmHg],daytime SBP[（143.3±12.7）mmHg vs.（158.2±9.1）mmHg],night SBP[（136.6±9.4）mmHg vs.（150.7±10.1）mmHg],LVMI[（101.76±34.45）g/ m2 vs.（138.13±37.6）g/m2]and carotid IMT[（0.84±0.11）mm vs.（1.35±0.35）mm]in MBPS group,P＆lt; 0.05all;Pearson correlation analysis indicated that MBPS was positively correlated with LVMI and IMT（r= 0.688,0.524,P＆lt;0.05both）.Conclusion：Morning blood pressure surge could aggravate target organ damage in aged patients with essential hypertension.