超敏C反应蛋白及糖化血红蛋白与急性冠脉综合征的关系

Relationship among high sensitive C reactive protein,glycosylated hemoglobin and acute coronary syn drome

探讨超敏C反应蛋白(hsCRP)和糖化血红蛋白(HbA1c)与急性冠脉综合征(ACS)的关系。方法:选择冠心病(CHD)患者71例,分为ACS组(29例)和稳定型心绞痛(SAP)组(42例),根据冠脉造影结果,CHD患者又分为单支(31例)、双支(22例)和多支(18例)病变组,并另选择30例健康体检者作为正常对照组。检测各组hsCRP、HbA1c水平并进行比较。结果:与正常对照组和SAP组比较,ACS组患者血清hsCRP[(5.13±5.85)mg/L比(7.72±6.16)mg/L比(9.83±6.84)mg/L]及HbA1c[(5.36±0.33)mmol/L比(6.48±1.63)mmol/L比(7.20±1.53)mmol/L]水平明显升高(P<均0.05);与单支、双支血管病变组比较,多支血管病变的hsCRP[(6.62±6.44)mg/L比(9.52±6.91)mg/L比(10.63±7.56)mg/L]及HbA1c[(6.42±1.68)mmol/L比(6.82±4.62)mmol/L比(7.17±1.86)mmol/L]水平明显升高(P均<0.05)。结论:急性冠脉综合征患者血清超敏C反应蛋白和HbA1c水平升高明显,冠脉病变越重其水平越高,血清超敏C反应蛋白和HbA1c水平与急性冠脉综合征及冠脉病变程度有关联。

Objective：To explore the relationship among high sensitive C reactive protein（hsCRP）,glycosylated hemoglobin（HbA1c）and acute coronary syndrome（ACS）.Methods：A total of 71patients with coronary heart disease（CHD）were divided into ACS group（n=29）and stable angina pectoris（SAP）group（n=42）.According to results of coronary angiography,CHD patients were further divided into single-vessel（n=31）,double-vessel（n=22）and multi-vessel（n=18）coronary disease group.Another 30healthy subjects were regard as normal control group.Levels of hsCRP and HbA1cwere measured and compared among above-mentioned all groups.Results：Compared with normal control group and SAP group,there were significant increase in serum levels of hsCRP[（5.13±5.85）mg/L vs.（7.72±6.16）mg/L vs.（9.83±6.84）mg/L]and HbA1c[（5.36±0.33）mmol/L vs.（6.48±1.63）mmol/L vs.（7.20±1.53）mmol/L]in ACS group,P＆lt;0.05all;compared with single-vessel,double-vessel coronary disease group,there were significant increase in levels of hsCRP[（6.62±6.44）mg/L vs.（9.52±6.91）mg/L vs.（10.63± 7.56）mg/L]and HbA1c[（6.42±1.68）mmol/L vs.（6.82±4.62）mmol/L vs.（7.17±1.86）mmol/L]in multi-vessel coronary disease group（P＆lt;0.05all）.Conclusion：Serum levels of hsCRP and HbA1csignificantly increase in ACS patients.Serum levels of hsCRP and HbA1care related to ACS and coronary disease degree.