摘要
探讨有或无高血压的代谢综合征（MS）患者主动脉根部及心脏瓣膜病变特点及相关因素。方法：选择我院心内科住院患者350例,按有无高血压分为：无高血压代谢综合征组（MS组,142例）,高血压代谢综合征组（HMS组,208例）;并选择年龄50岁以上同期健康体检者作为健康对照组（60例）,比较三组主动脉根部内径、扩张比例以及心脏瓣膜退行性病变比例,并通过Logistic回归分析主动脉根部扩张的相关危险因素。结果：与健康对照组及MS组比较,HMS组的主动脉扩张病人比例（11.7%比25.4%比40.9%）,主动脉根部扩张比例[（27.5±2.6）mm比（29.1±2.3）mm比（32.8±3.4）mm]显著增加（P〈0.05）。HMS组瓣膜退行性变的比例明显高于MS组（47.8%比31%,P〈0.05）,以主动脉瓣和联合瓣膜病变为主。Logistic多因素回归分析发现,年龄（MS组：OR=1.57,HMS组：OR=1.46）、血脂紊乱（低密度脂蛋白胆固醇：MS组：OR=9.48,HMS组：OR=1.97）、高血压（MS组：OR=1.79/0.81,HMS组：OR=1.79/1.03）是主动脉根部扩张的危险因素（P〈0.05~〈0.01）。结论：高血压是代谢综合征患者主动脉根部扩张的危险因素之一,也与瓣膜退变有关。
Objective：To explore characters of aortic root and heart valvular lesion in patients with metabolic syndrome（MS）and their relative factors.Methods：A total of 350inpatients of our department were enrolled.According to hypertension or not,they were divided into MS without hypertension group（MS group,n=142）and hypertension＋ MS group（HMS group,n=208）;another 60normal subjects with age＆gt;50years were regard as healthy control group.Logistic regression analysis was used to analyze relative risk factors of aortic root dilation.Results： Compared with healthy control group,ratio of patients with aortic dilation（11.7% vs.25.4% vs.40.9%）,ratio of aortic dilation[（27.5±2.6）mm vs.（29.1±2.3）mm vs.（32.8±3.4）mm]significantly increased in MS group（P＆lt;0.05）.Compared with MS group,there was significant increase in percentage of valvular degenerative lesion（31% vs.47.8%,P＆lt;0.05）in HMS group,and they were mainly aortic valve and combined valvular lesion.Logistic multi-factor regression analysis found that age（MS group：OR=1.57,HMS group：OR=1.46）,dyslipidemia（LDL：MS group：OR =9.48,HMS group：OR =1.97）,hypertension（MS group：OR =1.79/0.81,HMS group：OR=1.79/1.03）were risk factors for aortic root dilation（P＆lt;0.05~0.01）.Conclusion：Hypertension is one of risk key factors leading to aortic root dilation and also related with valvular degeneration.
出处
《心血管康复医学杂志》
CAS
2013年第4期387-390,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
