左西孟旦治疗老年慢性心力衰竭患者的疗效分析

Curative effect of levosimendan on aged patients with chronic heart failure

目的:研究国产左西孟旦注射液治疗老年慢性心力衰竭(CHF)患者的有效性。方法:60例CHF患者被随机分为左西孟旦组(30例)和多巴胺组(30例),分别静脉滴注左西孟旦,多巴胺24h。观察两组左心室射血分数(LVEF)、每搏心输出量(SV)、左室收缩末内径(LVESd)、左室舒张末内径(LVEDd)及血浆N-末端脑利钠肽(NT-proBNP)等指标治疗前后的变化。结果:与治疗前比较,两组LVEF均显著升高(P<0.05),但两组间无显著差异(P>0.05)。与多巴胺组比较,左西孟旦组SV[(63.12±24.21)ml比(70.12±24.26)ml]显著升高,NT-proBNP[(4342.49±561.08)pg/ml比(4045.11±432.55)pg/ml]水平显著降低(P均<0.05)。结论:左西孟旦能增加心力衰竭患者的心肌收缩力,改善心功能,显著降低血浆N-末端脑利钠肽水平。

Objective：To study the efficacy of domestic levosimendan injection on aged patients with chronic heart failure（CHF）.Methods：A total of 60CHF patients were randomly divided into levosimendan group（n=30）and dopamine group（n=30）,and patients of these two groups respectively received intravenous infusion of levosimendan and dopamine for 24h.Changes of left ventricular ejection fraction（LVEF）,stroke volume（SV）,left ventricular end-systolic dimension（LVESd）,left ventricular end-diastolic dimension（LVEDd）and plasma level of N terminal pro brain natriuretic peptide（NT-proBNP）were observed in two groups.Results：Compared with before treatment,there was significant increase in LVEF（P＆lt;0.05）,but there was no significant difference between two groups（P＆gt;0.05）.Compared with dopamine group,there was significant increase in SV[（63.12±24.21）ml vs.（70.12±24.26）ml]and significant decrease in NT-proBNP level[（4342.49±561.08）pg/ml vs.（4045.11± 432.55）pg/ml]in levosimendan group,P＆lt;0.05both.Conclusion：Levosimendan can increase myocardial contractility,improve cardiac function and significantly decrease level of N terminal pro brain natriuretic peptide in patients with chronic heart failure.