摘要
目的:本实验通过研究E-钙黏蛋白及KLK7蛋白在子宫内膜癌中的表达,探讨其表达与子宫内膜癌的关系及临床意义。方法:将实验分为3组:16例增生期子宫内膜为正常组,30例不典型增生子宫内膜,35例子宫内膜癌,应用免疫组化SP染色方法检测E-Cad蛋白及KLK7蛋白在子宫内膜癌的表达及两者的关系。结果:与正常组比较,KLK7蛋白在不典型增生内膜及子宫内膜癌中的表达逐渐增高(P<0.05)。E-cad蛋白在不典型增生内膜及子宫内膜癌中的表达逐渐降低(P<0.05)。结论:通过本实验研究可知:KLK7蛋白和E-cad蛋白在子宫内膜癌的表达呈夫相关性,与子宫内膜癌的发生,发展密切相关,并为临床诊断及预后提出理论基础。
Objective：Through the research on the expressions of e-cadherin and KLK7 proteins in endometrial cancer,we intend to study the correlation between their expressions and endometrial cancer and their clinical significance.Methods：The experiment is divided into three groups： 16 cases of secretory endometrium as normal group,30 cases of endometrial atypical hyperplasia,and 35 cases of endometrial cancer.We applied immunohistochemical SP staining method for detecting the expressions of E-Cad protein and KLK7 protein in endometrial carcinoma and the relationship between the two.Results：Compared with the normal group,the expression of KLK7 in atypical hyperplasia of endometrium and endometrial carcinoma significantly increased（P〈0.05）.The expresion of E-cad protein in atypical hyperplasia of endometrium and endometrial carcinoma significantly reduced（P〈0.05）,and it＇s expression in endometrial carcinomas reduced more significantly.Conclusion：This study proves that the expressions of KLK7 and E-cad proteins show negative correlation in endometrial cancer,and closely relate with the occurrence and development of endometrial cancer,which offer theoretical basis for clinical diagnosis and prognosis.
出处
《黑龙江医药科学》
2013年第4期16-17,共2页
Heilongjiang Medicine and Pharmacy
基金
黑龙江省教育厅科学技术研究资助项目
编号:12511538
