通过体感诱发电位观察银杏达莫注射液治疗急性脑梗死的疗效

Observation on Effect of Ginkgo Dipyridolum Injection for Treating Acute Cerebral Infarction by Somatosensory Evoked Potential

目的通过体感诱发电位(SEP)评价银杏达莫注射液治疗急性脑梗死的疗效。方法将50例急性脑梗死患者随机分为两组各25例。对照组采用常规疗法。观察组加用银杏达莫注射液30mL+0.9%氯化钠注射液或5%葡萄糖注射液250mL静脉滴注,每天2次,连续2周。治疗前后行神经功能缺损程度评分,观察患者瘫痪肢体SEP的N20波变化。结果治疗后观察组神经功能缺损程度评分较对照组显著下降(P<0.05);观察组的总有效率为96.00%,显著高于对照组的72.00%(P<0.05)。治疗后2组患侧SEP的N20波幅都明显提高(P<0.01或P<0.05),治疗组升幅更高(P<0.05)。用药期间两组均未出现明显不良反应。结论银杏叶注射液对脑卒中后偏瘫患者脑功能的恢复疗效确切。

Objective To evaluate the curative effects of Ginkgo Dipyridolum Injection in the treatment of acute cerebral infarction by the somatosensory evoked potential（SEP）. Methods 50 patients with acute cerebral infarction were randomly divided into two groups,25 cases in each group. The control group was given the routine treatment. The observation group was added with Ginkgo Dipyridolum In- jection 30 mL plus 0. 9% sodium chloride injection 250 mL or 5% glucose Injection 250 mL by intravenous drip, twice a day for continuous 2 weeks. The neurological deficit score was conducted before and after treatment, the N20 wave changes of SEP in the para- lyzed limbs and body were observed. Results The neurological deficit scores after treatment in the observation group were decreased significantly compared with the control group（P 〈 0.05）;the total effective rate was 96.00% in the observation group,which was sig- nificantly higher than 72.00% in the control group （P 〈 0. 05）. The N20 wave amplitude of SEP after treatment in the two groups was elevated significantly（P 〈 0. 01 or P 〈 0. 05）,but the increase of the treatment group was higher（P 〈 0.05）. No obvious adverse reactions appeared during the treatment process. Conclusion Ginkgo Dipyridolum Injection has definite curative effect for the cerebral function recovery in the post- stroke hemiplegic patients.