摘要
目的为临床更安全使用抗栓药物提供参考。方法采用回顾性分析方法,查阅住院病历,对48例抗栓治疗相关性脑出血(ICH)患者的住院医嘱进行分析。结果引起抗栓治疗相关性脑出血最多的药物是阿司匹林,共36例;其次是氯吡格雷,共8例,华法林3例,低分子肝素4例。阿司匹林使用0.3g/d剂量的13例,0.2g/d的9例,0.1g/d的4例,中高剂量引起脑出血者例数较低剂量多;抗栓药物合用活血化瘀类中药注射剂患者较常见ICH。结论中等剂量到大剂量(≥0.3g/d)的阿司匹林以及抗栓药物合并活血化瘀类中药注射剂,可能会增加ICH的危险性。抗栓治疗应采用适合患者的治疗强度,最大限度地降低脑出血的发生。
Objective To analyze the medication condition of antithrombotic related intracerebral hemorrhage （ICH）. Methods By using the retrospective analysis method and referring to the medical records,48 inpatients with antithrombotic related ICH were analyzed on the medical orders during hospitalization period. Results The most of drug leading to antithrombotic related ICH was aspirin （n =36）, followed by clopidogre （ n = 8 ）, warfarin （ n = 3 ） and nadroparin calcium （ n = 4）. The used aspirin dose was 0. 3 g / d in 13 cases, 0.2 g/d in 9 cases and 0. 1 g/d in 4 cases. The ICH cases induced by middle and high dose of aspirin were more than those by low dose. ICH was commonly found in the patients with the antithrombotic drugs combined the Chinese medicine injections of activating blood circulation to dissipate blood stasis. Conclusion Middle and high dose of aspirin（ 〉~ 0. 3 g/d） and antithrombotic drugs combined with Chinese medicine injections of activating blood circulation to dissipate blood stasis could increase the risk of ICH. The antithrom- boric therapy should adopt the treatment intensity suitable for the patient in order to reduce the occurrence of ICH to maximal limit.
出处
《中国药业》
CAS
2013年第16期80-82,共3页
China Pharmaceuticals
关键词
抗栓药物
脑出血
合理用药
antithrombotic drug
intracerebral hemorrhage
rational medication
