新肿瘤抑制基因SLC5A8研究进展

Research progress of the new tumor suppressor gene SLC5A8

目前研究认为，SLC5A8是一种新的候选肿瘤抑制基因，在人类的甲状腺癌、食管癌、胃癌、结肠癌和急性髓系白血病中表达降低或缺失。该基因位于人类染色体12q13—23编码蛋白，属于Na^＋／葡萄糖共转运蛋白家族成员，是Na^＋耦联的转运短链脂肪酸、乳酸、烟酸和碘化物的载体。其外显子1的GPG岛的甲基化及组蛋白去乙酰化可使SLC5A8基因表达沉默，促进肿瘤的发生。SLC5A8表达的转运体的所有底物中，丁酸、丙酸和丙酮酸的功能是作为组蛋白脱乙酰基酶抑制剂，它们可以介导多种肿瘤细胞的凋亡，可能为其抑制肿瘤的机制。

Current research suggests that SLC5A8 is a new candidate tumor-suppressor gene whose expression is reduced or deficient in human thyroid cancer, esophageal cancer, gastric cancer, colon cancer and acute myeloid leukemia. The gene is in human chromosomes 12q13-23, and encoding proteins that be- longs to the members of the family of sodium/glucose transporters. It is sodium -coupled carrier that transfer short chain fatty acid, lactic acid, nicotinic acid and iodide. The exon 1 of GPG island methylation and histone acetylation can make SLC5A8 gene express silenced and promote the occurrence of tumor, of all transporter substrates of SLC5A8 expresses, butyrate, propionate and pyruvate function as histone deacetylase inhibitors and can be mediated apoptosis of many kinds of tumor ceils, which may be the mechanism of inhibiting tumor.