DNT细胞在免疫治疗中的研究进展

Progress of DNT cells on immunotherapy

调节性T细胞在调节免疫反应中有着非常重要的作用，近来新发现一类特殊的调节性T细胞，它们的细胞表型为TCRαβ^＋CD3^＋CD4-CD8-NK1．1-，即DNT细胞。DNT细胞能够抑制CD4^＋、CD8^＋、B、NK和树突状细胞，从而在多种疾病免疫调节如自身免疫性疾病、感染、炎性疾病、移植免疫和肿瘤免疫等发挥着重要的作用，近年来DNT细胞已成为免疫治疗研究新的热点。本文主要就DNT细胞的可能来源及发挥调节作用的机制作进一步的阐述。

Regulatory T cells play an important role in regulating immune responses. Recently, a novel immune Treg cell with phenotype TCRαβ CD3^＋ CD4- CD8- NK1.1 - was known as the Double-negative T cells （DNT）. DNT cells are able to suppress CD4^＋ and CD8^ ＋ T cells, B cells as well as NK cells and dendritic cells（DCs） and play an important role in regulating immune responses in models of autoimmunity, infection, inflammatory disease, transplantation and tumor immunity. Now DNT ceils have already become a hot point in the research of the immuno- therapy. This article mainly introduces the possible sources of DNT cells and the mechanisms of their functions.