臭氧参与NAD^+/NADH氧化还原反应机理的理论研究

Theoretical Discussion on Mechanism of the Reaction of Ozone and NAD^+/NADH

NAD+/NADH是细胞能量代谢所必需的辅酶,NAD+/NADH的水平对细胞的节律、衰老、癌变和死亡等重大生命过程有着直接的影响。臭氧作为外来因素可使NADH进行刺激响应。介绍了NADHHE臭氧对生物分子的作用机理,对臭氧直接参与NAD+/NADH氧化还原反应的机理进行了理论研究,为进一步的实验研究提供参考。

NAD ^＋/NADH is a kind of necessary coenzyme in cellular energy metabolism, and it has been shown by numerous studies that cellular redox state especially NAD ^＋/NADH level may be a pri-mary control site in numerous biological process linked to rhythm, senescence, cancer and death. O-zone as a external factors can make the NADH stimulate response. Because of experimental condi-tions, the mechanism of the reaction of ozone and NAD^＋/NADH can be studied by theoretical chem-istry. According to the literature research, overall reaction NADH ＋ O3→, NAD^＋ HO· ＋ O2 is the proton combined with electron transfer reaction, which has important significance to promote the dynamics of biological reaction using density functional theory on reaction mechanism research.