蔗糖铁注射液治疗维持性血液透析患者肾性贫血的疗效观察

The efficacand safetof iron sucrose inection and ferrous succinate tablets in the treatment of renal anemia in mai ntenance hemodialysis

目的比较蔗糖铁注射液与琥珀酸亚铁片治疗维持性血液透析患者肾性贫血的疗效与安全性。方法维持性血液透析存在肾性贫血患者46例随机分为2组,观察组23例给予蔗糖铁注射液静脉注射,对照组23例给予琥珀酸亚铁片口服,观察治疗8周后2组患者血红蛋白(Hb)、红细胞压积(HCT)、网织红细胞(Ret)、血清铁(SI)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)及肝功能指标和不良反应。结果治疗后观察组患者Hb、HCT、Ret、SI、SF和TSAT均较治疗前上升(P<0.05),且观察组高于对照组(P<0.05);对照组Hb、HCT、SF、TAST均显著改善(P<0.05),而Ret、SI无显著改善;观察组患者不良反应发生率为8.7%(2/23),低于对照组的34.8%(8/23)(P<0.05);治疗前后2组患者的肝功能各项指标无显著变化(P>0.05)。结论蔗糖铁注射液治疗维持性血液透析患者肾性贫血的临床疗效较口服琥珀酸亚铁片好,且不良反应的发生率较低,值得临床推广应用。

Objective To compare the clinical efficacy and safety of iron sucrose injection and ferrous succinate tab- lets in the treatment of renal anemia in maintenance hemodialysis. Methods 46 cases of renal anemia in maintenance hemodi-alysis were selected during the period from October 2010 to June 2012 in the hospital. They were randomly divided into the ob- servation group （23 cases） and the control group （23 cases）. The observation group was treated with iron sucrose injection and the control group was treated with ferrous succinate tablets. After 8 weeks, observe the hemoglobin （ Hb）, hcmatocrit （HCT）, reticulocyte （Ret）, serum iron （IS）, serum ferritin （SF）, transferrinsaturation （TSAT） and adverse reactions, Re- suits After treatment, all the patients had certain clinical efficacy, Hb, HcT, Ret, SI, SF and TSAT of the two group in- creased significantly than before treatment, the difference was statistically significant （ P 〈 0.05） ; the Hb, HCT, Ret, SI, SF and TSAT of the observation group was significantly higher than those of the control group, the difference was statistically significant （ P 〈 0.05 ） ; the adverse reaction rate of the group was 8.7% （2/23） lower than 34.8% （8/23） of the control group, the difference was statistically significant （ P 〈 0. 05 ） ; the patientg liver function indicators did not change significant- ly before and after treatment, the above indicators of the observation group had no significant difference with that of the control group, the difference was not statistically significant （ P 〉 0. 05）. Conclusion Iron sucrose injection in the treatment of re- nal anemia in maintenance hemodialysis has better clinical efficacy than ferrous succinate tablets, and had a lower incidence of adverse reactions, it worth popularized in the clinical apphcmion.