直肠癌根治术后肝转移的危险因素分析

Risk factors of liver metastasis after radical resection of rectal carcinoma

目的分析影响直肠癌根治术后肝转移的危险因素。方法对本院2005年9月至2010年8月收治的97例患者进行回顾分析,分析肝转移发生的相关危险因素。结果比较未发生肝转移与发生肝转移患者的一般临床特征,发现年龄、血型、肝功能指标、肿瘤分化程度及肿瘤大小等差异均无统计学意义(P>0.05),而两组浸润深度差异有统计学意义(P<0.05),肝转移患者浸润深度较深,显示出该因素易引发术后肝转移。对出现肝转移患者的临床指征进行单因素回归分析,可见除淋巴结转移外(P<0.05),Dukes分期、血管神经侵犯等均非影响直肠癌根治术后肝转移的独立危险因素(P>0.05)。结论淋巴结转移情况及浸润深度是影响直肠癌根治术后肝转移的主要因素,出现淋巴结转移、肿瘤侵袭深度增加,则术后肝转移发生率上升。

Objective To explore the risk factors of hepatic metastasis after radical resection of rectal cancer.Methods Clinical data of 97patients,receiving radical resection of rectal cancer during Sep.2005and Aug.2010in this hospital,were retrospectively analyzed to identify risk factors of hepatic metastasis.Results Between patients with or without hepatic metastasis,the differences of age,blood type,liver function,differentiation degree of cancer and primary lesion size were all without statistical significance（P0.05）,but the difference of invasion depth was significant（P0.05）.Single factor analysis indicated that,except lymph node metastasis（P0.05）,other factors,such as Dukes stage,vascular nerve invasion and so on,were not independent factors influencing hepatic metastasis（P0.05）.Conclusion Lymph node metastasis and invasion depth could be the factors influencing hepatic metastasis after radical resection of rectal carcinoma.The rate of liver metastasis could be increased with lymph node metastasis and the increasing of invasion depth.