外用重组人粒细胞巨噬细胞刺激因子凝胶治疗浅Ⅱ度烫伤的药效学考察

Study on Pharmacodynamics of rhGM-CSF Hydrogel for Topical Application Used for the Treatment of Superficial Ⅱ Degree Burn

目的:考察外用重组人粒细胞巨噬细胞刺激因子(rhGM-CSF)凝胶与磺胺嘧啶锌霜剂对大鼠浅Ⅱ度烫伤的药效学差异。方法:30只SD大鼠随机分为空白组、磺胺嘧啶锌霜剂组、外用rhGM-CSF凝胶组,每组10只。采用将大鼠脱毛区置于85℃恒温水浴中15 s的方法制成10%体表面积浅Ⅱ度烫伤模型,观察用药前后的心率、痛阈以及创面愈合时间、愈合率等是否具有统计学差异。结果:与磺胺嘧啶锌霜剂相比,外用rhGM-CSF凝胶对大鼠心脏影响较小;创面愈合的平均时间明显缩短,为(17±1.08)天;在烫伤用药后第20天痊愈率为100%。结论:外用rhGM-CSF凝胶对大鼠浅Ⅱ度烫伤具有较好的治疗效果。

Objective： To explore the pharmacodynamic differences between rhGM-CSF Hydrogel for Topical Application and Zinc sulfadiazine cream when used in the treatment of superficial Ⅱ degree burn in rats. Methods： Thirty SD rats were randomly divided into blank group, Zinc sulfadiazine cream group and rhGM-CSF Hydrogel for Topical Application group （n=10）. The hair removal area of rats was scalded in 85℃ water bath for 15 s, producing a superficial Ⅱdegree burn model. The heart rate before and after the medication, changes of pain threshold, wound healing and cure rate were analyzed for statistical differences. Results： Compared to Zinc sulfadiazine cream, rhGM-CSF Hydrogel for Topical Application had less influence on rats＇ hearts and the average time of wound healing was significantly shorter, which was 17±1.08 days. On the twentieth day, the cure rate of rhGM-CSF Hydrogel for Topical Application was 100%. Conclosion： The rhGM-CSF Hydrogel for Topical Application had a better therapeutic effect on the superficial Ⅱ degree burn in rats.