不同时间睡眠剥夺对健康男性血清皮质醇及认知功能的影响

Effects of Sleep Deprivation at Different Time During Night on Serumcortisol and Cognition Function of Healthy Men

目的研究部分睡眠剥夺对健康男性血清皮质醇及认知功能的影响。方法采用交叉设计的自身对照性试验研究,14例健康男性先进入上半夜睡眠剥夺,经过7d睡眠洗脱期,进入下半夜睡眠剥夺。每个睡眠剥夺包括7d。每个睡眠剥夺晨起7:00时抽取空腹血测定血清皮质醇,每日12:00时行快速敲击键盘任务,单词记忆和单词识别测试。结果睡眠剥夺均导致皮质醇的下降,剥夺下半夜睡眠比上半夜更明显,恢复睡眠后,皮质醇恢复到未剥夺前的状态,睡眠剥夺均导致记忆、操作能力和注意力的下降,剥夺上半夜睡眠表现更为明显。结论睡眠剥夺对机体的认知功能和血清皮质醇的分泌存在明显影响。

Objective To investigate the effects of short-term sleep deprivation（SD）at different time during night on serum cortisol level and cognition function of healthy men .Methods Crossover design their own controlled trial was used,14 healthy men were first to enter the late-sleep deprivation,after a washout period of seven days of sleep into the midnight sleep deprivation,each sleep deprivation include 7 days.Early morning 7：00 fasting blood serum cortisol was collected after each sleep deprivation.The daily 12：00 line quick keystrokes task,word memory and word recognition test were taken.Results The cortisol levels lowered after 2 types of SD,and more obviously of deprivation the midnight sleep than the late-sleep,Cortisol recover to the state of not deprive after sleep recovery .Sleep deprivation lead to a de-cline in memory,operating capacity and attention,deprive midnight sleep became more evident .Conclusion Sleep dep-rivation significantly affect the body cognitive function and serum cortisol secretion .