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高尿酸血症相关肾病研究新进展 被引量:7

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摘要 随着经济的发展和生活水平的提高,高尿酸血症发病率显著增加,其中多数是无痛风发作的轻到中等程度的高尿酸血症。近十年来,国际上许多流行病学、动物实验或体外细胞生物学研究结果显示长期轻度高尿酸尿症(mild hyperuricemia)也可能引起慢性肾脏病。最近已有不少研究发现,基础尿酸水平升高与高血压、全身炎症反应、内皮细胞功能不良、病理性血管重构有关¨.2]。尿酸具有促炎作用,可通过单核细胞趋化蛋白-1(MCP-1)、生长因子、促分裂原活化蛋白激酶(MAPK)、环氧化酶-2(COX-2),刺激小鼠平滑肌细胞增殖^【3,4】
作者 邹和群
出处 《中国中西医结合肾病杂志》 2013年第8期732-734,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
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参考文献24

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二级参考文献17

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