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糖皮质激素与口服环磷酰胺联合治疗过敏性紫癜63例疗效观察 被引量:3

Curative effect observation of glucocorticoid combined with oral cyclophosphamide in the treatment of henoch-schonlein purpura in 63 cases
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摘要 目的探讨糖皮质激素与口服环磷酰胺联合使用对过敏性紫癜的临床治疗效果。方法回顾分析我院收治的63例发生过敏性紫癜的患儿临床采用糖皮质激素与口服环磷酰胺进行治疗的效果。结果本研究选取的所有患儿在经过糖皮质激素或环磷酰胺治疗5~10d后,皮肤紫癜、腹痛、关节痛等症状均已完全消失,3—12周内蛋白尿、血尿消失,总有效率为100%;停药后1年内有12例患儿复发,所有复发者均没有采用环磷酰胺进行治疗,对于复发的患儿均采用环磷酰胺加泼尼松进行联合治疗,经过4—8周治疗后,所有患儿均已痊愈,随访1年,均没有发生复发,在本研究中,痊愈患儿有51例,占80.95%;有效12例,占19.05%;无效0例。结论采用糖皮质激素与口服环磷酰胺联合治疗过敏性紫癜安全可靠,值得临床推广。 Objective To discuss the clinical therapeutic effect of glucoeortieoid combined with oral cyclophosphamide in the treatment of henoeh-schonlein purpura. Methods The therapeutic effect of 63 children with henoch-schonlein purpura who were treated with glucocorticoid combined with oral cyclophosphamide in our hospital were retrospectively analyzed. Results The skin purpura, abdominal pain and joint pain symptoms of all children at 5-10 days after glucoeorticoid combined with oral cyclophosphamide treatment disappeared completely, proteinuria and hematuria disappeared within 3-12 weeks, and the total effective rate was 100%;12 cases relapsed within a year after discontinue medication, all relapsed cases had not been used cyclophosphamide treatment and were given cyclophosphamide combined with prednisone treatment. After 4-8 weeks of the treatment, all children had been cured, and no relapse occurred within 1 year follow-up. In this study, there were 51 cases(80.95%) of recovery and 12 cases(19.05%) in effective, no a case invalid. Conclusion Glucocorticoid combined with oral cyclophosphamide in the treatment of henoch-sehonlein purpura is safe, reliable and worthy of clinical widely popularization.
作者 马春华
出处 《中国医药科学》 2013年第17期98-99,104,共3页 China Medicine And Pharmacy
关键词 糖皮质激素 环磷酰胺 过敏性紫癜 Glucocorticoid Cyclophosphamide Henoch-schonlein purpura
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  • 1姜新猷.环磷酰胺冲击疗法治疗小儿难治性肾病综合征[J].临床儿科杂志,1993,11(4):229-230. 被引量:23
  • 2竺培青,何威逊,朱光华,罗运九,方明俊.特异性IgE在儿童过敏性紫癜病因诊断中意义[J].临床儿科杂志,2005,23(3):164-164. 被引量:28
  • 3王群,李雄,彭娟.强的松与氢化可的松治疗儿童腹型过敏性紫癜的疗效比较[J].华夏医学,2006,19(1):105-106. 被引量:6
  • 4封锡春 严义培.长春新碱加激素治疗重型及迁延型过敏性紫癜16例[J].中华儿科杂志,1999,37(2):120-120.
  • 5胡亚美,江载芳,主编.诸福棠实用儿科学.上册.第七版.北京:人民卫生出版社,2005:668.
  • 6Niaudet P, Habib R. Methylprednisolone pulse therapy in the treatment of severe forms Schonlein -Henoch purpura nephritis. Pediatr Nephrol, 1998 ; 12 ( 3 ) :238-243.
  • 7Patrick N, Rene H. Methylprednisolone pulse therapy in the treatment of severe form of Henoch-Schonlein purpura nephritis. Pediatr Nephrol, 1998,12(3) :238~240.
  • 8Goldstein AR, White RHR, Akuse R, et al. Long-term follow -up of childhood Henoch- Schonlein nephritis. Lancet, 1992,339:280~282.
  • 9Berenbaum MC, Brown IN. Dose response relationships for agents inhibiting the immune response. Immunology, 1964,7: 65.
  • 10Radovan Bogdanovic, et al. Testicular function following cyclophosphamide treatment for childhood nephritic syndrome: longterm follow- up study. Pediatr Nephrol, 1990,4 :451

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