对比美托洛尔和卡维地洛治疗心力衰竭的临床效果

Comparative analysis on clinical effect of metoprolol and carvedilol treating heart failure

目的探讨美托洛尔和卡维地洛治疗心力衰竭的临床效果。方法选取我院2010年6月～2012年6月收治的84例心力衰竭患者，随机分为观察组与参考组，各为42例，参考组患者给予美托洛尔治疗，观察组患者采用卡维地洛治疗，比较两组患者的治疗效果及不良反应发生率、心功能。结果观察组患者治疗有效率为83．3％，参考组患者治疗有效率为66．7％，两组比较差异有统计学意义（P〈0．05）；观察组患者治疗中出现3例不良反应，参考组患者出现9例不良反应，比较差异有统计学意义（P〈0．05），观察组患者心功能康复明显优于参考组，差异有统计学意义（P〈0．05）。结论卡维地洛治疗心力衰竭效果优于美托洛尔治疗，并发症发生率较低，安全有效，值得推广。

Objective To compare and analyze the clinical effect of metoprolol and carvedilol treating heart failure. Methods 84 cases with heart failure treated in our hospital from June 2010 to June 2012 were selected randomly and divided into two groups, the observation group and the control group,each group for 42 cases. The control group were treated with metoprolol, and the observation group were treated with carvedilol. The treatment effect,adverse reaction incidence rate and heart function of two groups were compared. Results The effective rate of the observation group was 83.3%,and that of the control group was 66.7%,which had evident difference（P 〈 0.05）. There were 3 cases with adverse reactions in the observation group, and 9 cases with adverse reactions in the control group, which had evident difference（P 〈 0.05）. Rehabilitation of cardiac function in the observation group was better evidently than that of the control group（P 〈 0.05）, which had statistical significance. Conclusion Carvedilol treating heart failure not only is better than metoprolo, but also has low incidence rate of complications, and is safe and effective, which is worthy of promotion.