炎琥宁注射液辅助治疗小儿上呼吸道感染50例效果分析

Effect analysis on yanhuning injection in adjuvant treatment of 50 children with upper respiratory infection

目的评价大环内脂类抗生素或B-内酰胺类加抗病毒药物如利巴韦林与炎琥宁注射液辅助治疗小儿上呼吸道感染（AURI）的临床效果。方法择选我院AURI共50例（其中男28例，女22例），随机均分为两组，对照组25例，治疗组25例。对照组为常规治疗，治疗组为炎琥宁注射液加常规治疗，疗程均为3d。炎琥宁注射液（5～10）mg／kg·d加入5％葡萄糖50—100mL静脉滴注，1．5次／d左右静脉滴注。认真观察对照组与实验组患儿治疗后的症状缓解状况，然后对两组患儿血液常规检查进行对比分析，最后根据疗效评价标准对两组疗效进行评价。结果对照组治疗有效率为68．00％，治疗组治疗有效率为96．00％，两组治疗有效率比较差异有统计学意义（P〈0．05）。经统计学检验，治疗组的疗效显著优于对照组为，差异有统计学意义（P〈0．05）。本研究患儿的治疗中对照组患者共出现3例（12．0％）胃肠道不适者，3例患儿出现皮疹（12．0％），其他2例（8．0％），不良反应率为32．0％；治疗组1例（4．0％）治疗组皮疹，无其他不良反应，不良反应率为4．0％。治疗组不良反应率较对照组明显降低。治疗组发热、鼻塞流涕、白细胞计数等恢复正常的时间比对照组短，差异有统计学意义（P〈0．05）。结论常规治疗方法加中成药炎琥宁注射液治疗小儿上呼吸道感染有显著疗效，同时还可以大大降低目前我国的基层医疗机构滥用抗生素。该药的治疗效果安全可靠，见效快，不良反应少的优点，值得临床推广用药。

Objective To evaluate the clinical effect of macrolide antibiotic or 13 -lactam antibiotic and antiviral drugs such as ribavirin and yanhuning injection in adjuvant treatment of children acute upper respiratory infection （AURI）. Methods 50 children with AURI in our hospital, of which 28 boys and 22 girls, were randomly divided into two groups, 25 patients in the control group and 25 patients in the treatment group. The patients in the control group received conventional treatment for three days, while the patients in the treatment group received yanhuning injection and conventional treatment for three days. The usage of yanhuning injection was 5 10mg/ （ kg d ） yanhuning injection diluted with 50100mL 5% glucose injection intravenous drip 1.5 times daily. The symptom relief of patients after the treatment in the control group and the treatment group were carefully observed, blood routine examination of two groups were compared and analyzed, then the efficacy of two groups were evaluated according to efficacy evaluation standards. Results The treatment effective rate of the control group was 68.00%, the treatment effective rate of the treatment group was 96.00%, there was significant difference in the treatment effective rate between two groups（P 0.05）. The efficacy of the treatment group was statistically better than that of the control group, the difference was statistically significant （P 〈 0.05）. In the treatment of patients, there were 3 cases （12.0%） with gastrointestinal discomfort, 3 cases （12.0%） with rash, 2 cases （8.0%） with other disease in the control group, the adverse reaction rate was 32.0%; there were 1 case （4.0%） with rash, no other adverse reactions, the adverse reaction rate was 4.0%. The adverse reaction rate of the treatment group was significantly lower than that of the control group. The time to normalization of fever, stuffy and running nose, white blood cell count in the treatment group were shorter than those in the control group, the differences were statistically significant（P 〈 0.05）. Conclusion Conventional treatment methods and yanhuning injection of Chinese patent drug in treatment of children upper respiratory infection has significant effect, but can also greatly reduce the misuse of antibiotics in basic medical institutions in China. The drug has the merits such as safe and reliable therapeutic effect, rapid onset, fewer adverse reactions, and it is worthy of clinical popularization and application.