4-氯代异喹啉类衍生物的合成与表征

Synthesis and Characterization of 4-Chloroisoquinolines

在PdCl_2/CuCl_2/Cy_2NH_2Cl的催化体系中,邻炔基苄基叠氮可以顺利地发生亲电环化反应选择性合成3-取代-4-氯代异喹啉,产率38%~84%,其结构经~1H NMR,^(13)C NMR和GC-MS袁征。该方法反应条件温和、操作简单,并且在产物骨架中引入卤原子,为新官能团的引入提供了途径。

In the presence of PdClz/CuC12/Cy2 NH2 C1, a variety of 2-alkynyl benzyl azides smoothly underwent electronic cyclization to afford corresponding 3-substituted 4-chloroisoquinolines in 38%-84% yields. The sturctures were confirmed by 1H NMR,13 C NMR and GC-MS. This method had many merits such as simple operation and mild reaction condition. Importantly, a halide group was introduced into the products which made the methodology more attractive for organic synthesis.