脑出血患者血浆8-表氧前列腺素F2α的检测及临床意义

Determination of plasma 8-Iso-Prostaglandin F2α concentration in patients with intracerebral hemorrhage and its clinical significance

目的揭示血浆8-表氧前列腺素F2α（8-iso-PGF2α）浓度与脑出血预后的关系。方法选取86例高血压性基底节出血患者为脑出血组，另选86例体检者为对照组。采用酶联免疫吸附法（ELISA）法检测血浆8-iso-PGF2α浓度，记录患者入院时格拉斯哥昏迷评分、血肿量、脑室积血及脑出血后3个月预后等资料。比较脑出血组和对照组血浆8-iso-PGF2α浓度的变化，分析脑出血患者3个月内死亡和预后不良的危险因素，评价血浆8-iso-PGF2α浓度对脑出血患者3个月内死亡及预后不良的预测价值。结果脑出血组血浆8-iso-PGF2α浓度为（576.69±229.98） pg/ml较对照组的（67.67±21.54）pg/ml明显升高，差异有统计学意义（t=22.37， P＜0.05）；脑出血后3个月内死亡16例（18.61%）、预后不良29例（33.72%）；入院时血浆8-iso-PGF2α浓度是脑出血后3个月内死亡（OR=1.28，95%CI为1.08～2.67， P＜0.05）和预后不良（OR=1.31，95%CI为1.10～2.99， P＜0.05）的独立危险因素。结论脑出血患者血浆8-iso-PGF2α浓度明显升高，与脑出血后3个月内死亡和预后不良有关。

Objective To discover relationship between plasma 8-Iso-Prostaglandin F2αconcentrations and prognosis of patients with intracerebral hemorrhage. Methods A total of 86 patients with hypertensive basal ganglia hemorrhage were recruited as intracerebral hemorrhage group, and in addition, 86 healthy individuals from physical examinees were chosen as the control group. Plasma 8-Iso-Prostaglandin F2α concentrations were measured using enzyme-linked immunosorbent assay. Clinical materials on admission including Glasgow Coma Scale scores, hematoma volume, and intraventricular hem-orrhage of the patients and 3-month prognosis post-intracerebral hemorrhage were recorded. The difference of plasma 8-Iso-Prostaglandin F2α concentration between intracerebral hemorrhage patients and healthy individuals was investigated. Logistic model was structured to analyze the risk factors of 3-month death and unfavorable outcome of patients with intrac-erebral hemorrhage. The predictive value of plasma 8-Iso-Prostaglandin F2αconcentration for 3-month death and unfavor-able outcome was analyzed using receiver operating characteristic curves. Results Plasma 8-Iso-Prostaglandin F2α con-centrations were obviously higher in intracerebral hemorrhage patients than that in the healthy controls （576.69±229.98 pg/ml vs. 67.67±21.54 pg/ml, t=22.37, P〈0.05）. 16 patients （18.61%） died and 29 patients（33.72%） had unfavorable out-come at 3 months. Logistic analysis selected plasma 8-Iso-Prostaglandin F2α concentration as independent predictive fac-tor for 3-month death（OR=1.28, 95%CI=1.08~2.67, P〈0.05） and unfavorable outcome （OR=1.31, 95%CI=1.10~2.99, P〈0.05）. Conclusions Plasma 8-Iso-Prostaglandin F2αlevel is enhanced in patients with intracerebral hemorrhage and is related to the 3-month death and unfavorable outcome of intracerebral hemorrhage.