精神分裂症患者睡眠障碍的影响因素分析

Influencing factors in schizophrenia patients with sleep-disorder

目的探讨精神分裂症患者睡眠障碍发生情况及其影响因素,为进一步干预提供临床依据。方法采用分层随机抽样法抽取160例精神分裂症患者,采用匹茨堡睡眠质量指数量表(PSQI)对纳入对象入院后1个月内的睡眠状况进行测评,同时采用一般情况调查表、阳性和阴性症状量表(PANSS)、副反应量表(TESS)进行调查,分析患者一般资料、TESS、PANSS与PSQI的关系。结果 160例患者PSQI评分阳性率达58.13%;经多元回归分析,TESS、PSQI的阳性症状评分、一般精神病理因子分以及患者性别、文化程度和发病情况5个因素进入了PANSS逐步回归方程,且性别和发病情况与PSQI评分呈负相关,PANSS的阳性症状和精神病理因子分、TESS评分和文化程度与PSQI评分呈正相关。结论精神分裂症患者睡眠障碍发生率较高。男性、高文化程度、首次发病患者更易发生睡眠障碍且程度更重。

Objective To explore the status and influencing factors of sleep-disorder in patients with schizophrenia for providing clinical data for further intervention. Methods A total of 160 patients with schizophrenia that sampled through stratified random sampling method were investigated with the Pittsburgh Sleep Quality Index（PSQI）, the Positive and Neg-ative Syndrome Scale（PANSS） and the Treatment Emergent Side Effect Scale（TESS）. The relationship among the scores of four questionnaires were analyzed. Results The positive rate of PSQI was 58.13% in the group. The multiple regression analysis showed that the scores of TESS, positive symptoms and general spirit pathological factors of PANSS, gender, level of education and morbidity entered into the regression equation. The gender and morbidity were negatively related to the score of PSQI. The scores of TESS, positive symptoms and general spirit pathological factors of PANSS and level of educa-tion were positively related to the score of PSQI. Conclusion The positive rate of sleep-disorder is high in the patients with schizophrenia. The sleep-disorder symptom is more serious among the patients who are a man, having higher level of education and attacking firstly.