糖尿病病程与慢性并发症之间的相关性分析

The correlation analysis of duration and chronic complication of diabetes

目的探讨不同病程糖尿病患者的临床特点以及病程对糖尿病患者并发症的影响。方法选取不同病程的糖尿病患者各403例,分别记录其基本临床资料,包括身高、体质量、血压、病程、家族史、并发症发生情况等,并检测血糖、血脂、糖化血红蛋白、血β2微球蛋白、尿β2微球蛋白、尿微量清蛋白等指标,对不同病程的糖尿病患者并发症发生情况及各项指标的检测结果进行比较。结果不同病程糖尿病患者的年龄、发病年龄及收缩压比较差异有统计学意义(P<0.05);反映肾脏功能的指标如血β2微球蛋白、尿β2微球蛋白、尿微量清蛋白在不同病程组之间也有明显差异;与血管病变有关的脂蛋白(a)在不同病程组间也有差异。随着病程的增加,糖尿病慢性并发症的发生率明显增加(P<0.05)。结论病程是糖尿病并发症的重要影响因素之一,随着糖尿病病程的增加会对身体其他器官产生一定的影响。

Objective To investigate the diabetes complications and clinical features of the different duration of diabetes.Methods 403patients with different duration of diabetes were selected to record basic clinical information,which including height,weight,blood pressure,duration of disease,family history,complications,etc.and detected glucose,lipids,glycosylated hemoglobin,bloodβ2 microglobulin,urinaryβ2microglobulin,urine albumin,insulin and C peptide.The above indicators of different course of diabetes were compared.Results The age,onset age of patients and systolic pressure were significantly different among diverse duration of diabetes（P0.05）.The indicators reflecting the function of kidney such as bloodβ2microglobulin,urineβ2microglobulin and urine microalbumin were significantly different among diverse duration of diabetes.With the increase of the duration of diabetes,the incidence of diabetes complications increased significantly with a statistically significant difference（P0.05）.Conclusion The duration of the disease is one of the important factors for diabetes complications.The increasing of duration of diabetes have an important impact.on other organs.