糖化血红蛋白、胱抑素C、尿微量清蛋白在糖尿病早期肾损伤中的临床价值

Clinial value on detection of glycosylated hemoglobin,cystation C and microalbuminuria in the early renal damage of diabetes mellitus

目的检测糖尿病患者糖化血红蛋白、胱抑素C、尿微量清蛋白,探讨血清三项在糖尿病肾病早期诊断中的价值。方法将糖尿病患者按尿蛋白水平分为3组,定量检测糖化血红蛋白、胱抑素C、尿微量清蛋白的浓度和阳性率,并将其结果与正常对照组进行比较。结果糖尿病患者尿蛋白阴性组、尿蛋白阳性组糖化血红蛋白、胱抑素C、尿微量清蛋白与正常对照组比较差异有统计学意义(P<0.05)。结论三者联合检测可作为诊断糖尿病早期肾损害敏感可靠指标,严格调整血糖浓度,改善代谢有助于延缓糖尿病肾功能损害。

Objective To detect glycosylated hemoglobin,cystation C and microalbuminuriain patients with diabetes mellitus and vestigate the application value of that in early diagnosis of diabetic nephropathies.Methods According to urine protein level,the patients with diabetes mellitus were divded into three groups.The glycosylated hemoglobin,cystation C、microalbuminuria for the quantitative determination.The concentration and positive rate were compared with the normal control group.Results Compared with normal control group,the glycosylated hemoglobin,cystation C、microalbuminuria of urine protein negative group,urinary protein positive group were statistically significant difference（P0.05）.Conclusion Glycosylated hemoglobin,cystation C、microalbuminuria of patients with diabetes mellitus can be reliable and sensitive signals of the early renal damage of diabetes mellitus,strict adjustment of blood glucose levels.improve metabolism help delay diabctes with impaired renal function.