血清PSA、TNF-α及骨标志物检测对前列腺癌骨转移患者的诊断意义

Diagnostic significance of serum PSA,TNF-alpha and bone markers of prostate cancer patients with bone metastases

目的探讨血清PSA、TNF-α及骨标志物检测对前列腺癌骨转移患者的诊断意义。方法选择老年男性前列腺癌患者76例,入选后分别检测所有对象前列腺特异性抗原(PSA)、肿瘤坏死因子α(TNF-α)及骨标志物水平,并进行Gleason评分及全身骨扫描。结果根据全身骨显像检查将所有入选患者分为骨转移组及无骨转移组,分别为36例及40例。骨转移组PSA、碱性磷酸酶(ALP)、Ⅰ型胶原交联羧基末端肽(ICTP)、TNF-α与无骨转移组比较差异有统计学意义(P<0.05)。中分化组的PSA、ALP、TNF-α与高分化组比较差异有统计学意义(P<0.05)。低分化组PSA、ALP、ICTP、TNF-α与中、高分化组比较差异有统计学意义(P<0.05)。相关性分析示ALP与PSA、TNF-α呈显著正相关(P<0.05),ICTP与PSA、TNF-α呈显著正相关(P<0.05)。结论前列腺癌肿瘤标志物升高对预测骨转移的发生具有较好的指示意义。

Objective To investigate diagnostic significance of serum Prostate specific antigen（PSA）,tumer necrosis factor-alpha（TNF-α）and bone markers in prostate cancer bone metastasis.Methods 76cases of elderly men with prostate cancer were selected to detect all objects PSA,TNF-αand bone marker levels and accepted Gleason score and whole body bone scan.Results based on whole body bone scintigraphy all patients were divided into groups of non-bone metastasis and bone metastases,which were 36cases and 40cases separately.PSA,alkaline phosphatase（ALP）,C-terminal telopeptide of typeⅠcollagen（ICTP）,TNF-αin bone metastasis group than those without bone metastasis had significant difference（P0.05）.PSA,ALP,TNF-αin moderately differentiated group compared with that in high differentiated group,which had statistical significance（P0.05）.PSA,ALP,ICTP,TNF-αof poorly differentiated group compared with the other groups,which had statistical significance（P0.05）.The correlation analysis showed that the ALP and PSA,TNF-alpha had a significant positive correlation（P0.05）,the ICTP with PSA,TNF-alpha had a significant positive correlation（P0.05）.Conclusion Elevated prostate cancer tumor markers had good instructions to predict bone metastasis.