血清降钙素原、超敏C反应蛋白及白细胞介素6在慢性阻塞性肺疾病急性加重期患者中的临床应用

Clinical application of serum procalcitonin,high-sensitivity c-reactive protein and interleukin-6 in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)及白细胞介素6(IL-6)的检测在诊断和治疗慢性阻塞性肺疾病急性加重期(AECOPD)中的临床价值。方法检测88例AECOPD组和72例正常对照组血清PCT、hs-CRP及IL-6的浓度,并比较以上各指标在AECOPD患者治疗前后的变化。结果 AECOPD组治疗前血清PCT、hs-CRP及IL-6水平与AECOPD组治疗后和正常对照组比较差异有统计学意义(P<0.05);AECOPD组治疗后血清PCT、hs-CRP水平与正常对照组比较差异无统计学意义(P>0.05),而治疗后血清IL-6水平与正常对照组比较差异有统计意义(P<0.05)。结论血清PCT、hs-CRP及IL-6在AECOPD患者经有效抗感染治疗后均可发生显著变化,检测血清PCT、hs-CRP及IL-6有助于AECOPD的早期诊断及疗效观察。

Objective To explore the clinical application of serum procalcitonin（PCT）,high-sensitivity c-reactive protein（hsCRP）and interleukin-6（IL-6）in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods 88 cases of patients as AECOPD group and 72cases healthy control group were tested by PCT,hs-CRP and IL-6.The changes of such indexes were observed in the patients before and after treatment of AECOPD.Results Serum PCT,hs-CRP and IL-6levels in the patients before treatment of AECOPD group compared with after treatment of AECOPD group and healthy control group,the difference was statistically significant（P〈0.05）.Serum PCT,hs-CRP levels in the patients after treatment of AECOPD group compared with healthy control group,the difference was not statistically significant（P〈0.05）,and there was statistical significance between the levels of IL-6in the patients after treatment of AECOPD group and healthy control group（P〈0.05）.Conclusion After the effective anti-infection treatment,serum PCT,hs-CRP and IL-6in patients with AECOPD can change significantly,the detection of serum PCT,hs-CRP and IL-6can contribute to early diagnosis and curative effect observation of AECOPD.