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4-吡啶乙酸盐酸盐的合成研究

Synthesis of 2-(pyridin-4-yl)acetic Acid Hydrochloride
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摘要 介绍了标题化合物的合成方法。以4-氯吡啶盐酸盐为起始原料,先与丙二酸二乙酯反应,再用盐酸水解脱羧得到目标化合物,并经MS和1H NMR对其结构进行了表征。本合成路线原料易得、操作简便,易于实现工业化生产。反应总收率37%。 In the paper, we introduced a approach to synthetize the title compound, was realized and manufactured from 4-chloropyridine hydrochloride via tow steps. Its structure was verified by MS and 1H NMR. This synthetic route has the advantages of convenient operation and mild reaction conditions. The total product yield was 37 %. This program is suitable for industrial production.
作者 柴慧芳 曾晓萍 滕明刚 段炼
机构地区 贵阳中医学院药学院
出处 《广东化工》 CAS 2013年第18期34-34,共1页 Guangdong Chemical Industry
基金 贵州省中药现代化项目 合同编号:黔科合中药字[2010]5022号 贵州省教育厅自然科学课题 合同编号:黔教合KY字[2012]044号 贵州省高层次人才科研条件特助经费项目 合同编号:TZJF-2010年-055号
关键词 4-吡啶乙酸盐酸盐 4-氯吡啶盐酸盐 合成 2-（pyridin-4-yl）aceticacidhydroehloride 4-chloropyridinehydrochloride synthesis
分类号 O626.3 [理学—有机化学]
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参考文献6

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二级参考文献16

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共引文献11

广东化工
2013年 第18期

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