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内皮素1及其受体在心血管疾病中作用的研究进展 被引量：30

Progress in Research of Role of Endothelin-1 and Its Receptors in Cardiovascular Diseases
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摘要 内皮素1(ET-1)是一种具有收缩血管作用的多肽,广泛表达于血管内皮细胞及平滑肌细胞,在心血管疾病及糖尿病等的发生、发展过程中发挥着重要作用。本文对ET-1及其受体的来源与代谢,在心血管疾病如高血压、肺动脉高压及冠心病中的作用进行综述,展望其临床应用前景。 Endothelin - 1 （ ET - 1 ）, a peptide composed of 21 animo - acid with vaso - contractile properties and widely expressed in endothelial cells and vascular smooth muscle cells, plays an important role in the occurrence and development of cardiovascular diseases, diabetes, etc. This paper reviews the source and metabolism of ET - 1 and its receptors, its role in cardiovascular diseases such as hypertension, pulmonary hypertension and coronary heart disease, and outlooks its clinical appli- cation prospects.
作者 陈芳 王丽 朱中玉 高传玉 王宪沛 徐予
机构地区 河南省人民医院心内科 河南中医学院
出处 《中国全科医学》 CAS CSCD 北大核心 2013年第26期3149-3151,共3页 Chinese General Practice
基金 河南省基础与前沿技术研究计划项目(112300410051) 郑州市科技创新团队资助项目(121PCXTD520)
关键词 内皮素 冠心病 高血压 肺性 高血压 综述 Endothelin Coronary disease Hypertension, pulmonary Hypertension Review
分类号 R541 [医药卫生—心血管疾病]
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参考文献25

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二级参考文献41

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共引文献68

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引证文献30

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中国全科医学
2013年 第26期

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