乙肝病毒前S1抗原及核心抗体IgM在临床诊断中的价值

Value of hepatitis B virus PreS1 antigen and core antibody IgM in clinical diagnosis

目的探讨乙肝病毒前S1抗原(PreS1-Ag)、乙肝病毒核心抗体IgM(HBcAb-IgM)在临床诊断中应用价值。方法对1068例乙型肝炎血清标志物阳性者,用酶联免疫法检测PreS1-Ag、HBcAb-IgM和乙肝血清标志物5项,对检测结果进行统计学分析。结果在HBsAg/HBeAg/HBcAb阳性组,PreS1-Ag和HBcAb-IgM的阳性率分别为81.55%和29.13%,明显高于HBsAg/HBeAb/HBcAb阳性组,阳性率分别为56.39%和5.90%(P<0.01);PreS1-Ag和HBcAb-IgM的阳性率在HBeAg阳性组,阳性率分别为79.69%和26.95%,明显高于HBeAg阴性组(P<0.01)。结论 PreS1-Ag和HBcAb-IgM与HBeAg具有很好相关性,与HBV 5项血清标志物联用有良好的应用前景。

Objective To discuss the application value of hepatitis B virus PreS1 antigen and core antibody IgM in the clinical diagnosis. Methods Among 1068 patients with positive type B hepatitis serum marker, their PreS1-Ag, HBcAb-IgM, and serum markers were detected by enzyme immunoassay. The detection results were statistically analyzed. Results In the positive HBsAg/ HBeAg/HBcAb group, the positive rates of PreS1-Ag and HBeAb-IgM were 64. 61% and 29. 13%, respectively, which were significantly higher than those of the positive HBsAg/HBeAb/HBcAb group （56.39% and 5.90%, P 〈 0.01 ）. The positive rates of PreS1-Ag and HBcAb-IgM in the positive HBeAg group were 79.69% and 26.95% ,respectively,which were significantly higher than those of the negative HBeAg group（55.54% and 6.03% ,P 〈 0. 01 ）. Conclusion There is a good correlation between PreS1-Ag and HBcAb-IgM and HBeAg. The application of PreS1-Ag and HBeAb-IgM combined with five HBV serum markers has a good prospect.