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超重/肥胖孕妇血清纤维连接蛋白检测对罹患先兆子痫风险的研究 被引量：1

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摘要 目的探讨测定超重/肥胖孕妇血清中纤维连接蛋白(FN)的水平来评价罹患先兆子痫的风险。方法选取132例血压正常的非先兆子痫孕妇(正常体重者80例,超重/肥胖者52例)和26例先兆子痫孕妇(正常体重者12例,超重/肥胖者14例),采用酶联免疫吸附法(ELISA)测检血清中的FN水平。结果未发生先兆子痫的孕妇中,超重/肥胖组与正常体重组相比,血清中FN与平均动脉压(MAP)均显著升高(P均<0.01),且超重/肥胖组孕妇血清中FN含量与MAP呈正相关(r=0.685,P<0.05)。而发生先兆子痫的孕妇,超重/肥胖组与正常体重组相比,血清中FN浓度无统计学差异(P>0.05);然而发生先兆子痫孕妇的血清中FN比正常孕妇显著增高(P<0.01),比正常孕妇中的超重/肥胖者也要明显升高(P<0.01)。结论血清中FN水平升高可能是先兆子痫的一种危险因素,特别是对于超重/肥胖的孕妇。
作者 岳保峰
机构地区 山西省平定县冶西镇计划生育服务站
出处 《中国临床研究》 CAS 2013年第9期948-950,共3页 Chinese Journal of Clinical Research
关键词 纤维连接蛋白 先兆子痫 孕妇 超重 肥胖 酶联免疫吸附法
分类号 R714.244 [医药卫生—妇产科学]
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参考文献14

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中国临床研究
2013年 第9期

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