左旋羟嗪盐酸盐的合成研究

Study on Synthesis of (R)-Hydroxyzine Hydrochloride

左旋羟嗪盐酸盐是羟嗪盐酸盐的R型光学异构体。以4-氯二苯甲酮为原料,经Leuckart反应、拆分、环合、去保护基、缩合等五步反应制得了左旋羟嗪盐酸盐,以R-(-)-4-氯二苯甲胺计的总收率为52.7%。

（R）-Hydroxyzine hydrochloride is the R-isomer of hydroxyzine hydrochloride. （R）-Hydroxyzine hydrochloride was synthesized from 4-chlorobenzophenone via five steps including Leuckart reaction, resolution, cyclization,taking off protecting groups, condensation. Calculated with respect to the amount of （R）-（-）- 4-ehlorobenzhydrylamine, the overall yield was 52.7 %.