血清CTRP9水平与冠心病的关系

Decreased serum CTRP9 levels are associated with coronary artery disease

目的:探讨血清补体C1q肿瘤坏死因子相关蛋白9(CTRP9)表达水平与冠心病的关系。方法:入选经冠状动脉造影证实的稳定型冠心病患者278例(冠心病组)和113例健康对照(对照组),采用酶联免疫吸附法(ELISA)检测血清中CTRP9的水平。结果:冠心病组CTRP9水平明显低于对照组(P<0.05);多元逻辑回归分析发现,CTRP9降低是冠心病的独立危险因素。结论:血清CTRP9水平降低与冠心病发生有关,CTRP1降低是冠心病的独立危险因素。

Objective： To investigate the relationship between serum levels of complement C1q tumor necrosis factor related protein （CTRP） 9 and coronary artery disease （CAD）. Methods： This study included 278 patients with angiographically documented CAD （CAD group） and 113 healthy controls （control group）. Serum levels of CTRP9 were analyzed by enzyme linked immunosorbent assay （ELISA）. Results：Serum levels of CTRP9 were significantly lower in CAD patients than in controls （P〈0.05）. Significant difference of CTRP9 was noted between 1-vessel disease and 3-vessel disease patients. Multivariate logistic regression analysis showed that decreased CTRP9 was an independent risk factor of CAD. Conclusion：Decreased serum CTRP9 levels are associated with the presence and severity of CAD.