摘要
目的:探讨血清补体C1q肿瘤坏死因子相关蛋白9(CTRP9)表达水平与冠心病的关系。方法:入选经冠状动脉造影证实的稳定型冠心病患者278例(冠心病组)和113例健康对照(对照组),采用酶联免疫吸附法(ELISA)检测血清中CTRP9的水平。结果:冠心病组CTRP9水平明显低于对照组(P<0.05);多元逻辑回归分析发现,CTRP9降低是冠心病的独立危险因素。结论:血清CTRP9水平降低与冠心病发生有关,CTRP1降低是冠心病的独立危险因素。
Objective: To investigate the relationship between serum levels of complement C1q tumor necrosis factor related protein (CTRP) 9 and coronary artery disease (CAD). Methods: This study included 278 patients with angiographically documented CAD (CAD group) and 113 healthy controls (control group). Serum levels of CTRP9 were analyzed by enzyme linked immunosorbent assay (ELISA). Results:Serum levels of CTRP9 were significantly lower in CAD patients than in controls (P〈0.05). Significant difference of CTRP9 was noted between 1-vessel disease and 3-vessel disease patients. Multivariate logistic regression analysis showed that decreased CTRP9 was an independent risk factor of CAD. Conclusion:Decreased serum CTRP9 levels are associated with the presence and severity of CAD.
出处
《国际心血管病杂志》
2013年第5期323-325,共3页
International Journal of Cardiovascular Disease