摘要
目的 :探讨麻杏石甘滴丸与栓剂的体外释药规律。方法 :采用转篮法测定两者的体外溶出度 ,用酸性染料比色法测定制剂中麻黄总生物碱的含量并以此作为溶出指标。结果 :滴丸的 45min内溶出量达 10 0 %。栓剂的 45min内溶出量达92 .5 8%。结论 :两者的T50 ,Td 有显著性差异 (P <0 .0 5 ) ,滴丸溶出快于栓剂。
Objective: To explorate the drug releasing rule in vitro of Maxingshigan Dropping pill and Suppository. Methods: Their dissolution rates in vitro were determined by the rotary basket method, the contents of total alkaloid in ephedra alkaloid in the two preparations were determined by acidic dye colorimetry, and they were used as markers of dissolution.Results:The dissolution quantity in 45 min of Dropping pill reached 100%, whereas that of suppository reached 92.58%. Conclusion: T 50 , T d of the two preparations showed significant difference ( P <0.05). The dissolution rate of dropping pill was faster than that of suppository.
出处
《中成药》
CAS
CSCD
2000年第12期833-835,共3页
Chinese Traditional Patent Medicine
关键词
麻杏石甘
滴丸
体外溶出度
栓剂
中药
Maxingshigan Dropping pill
Maxingshigan Suppository
dissolution rate in vitro
rotary basket method
Ephedra alkaloid
acidic dye colorimetry
