盐酸莫西沙星对肺部感染老年患者QTc的影响

Effect of moxifloxacin hydrochloride on QTc in elderly patients with pulmonary infection

目的 探讨盐酸莫西沙星对肺部感染老年患者校正QT 间期（QTc）的影响.方法 选择192例因肺部感染于我院住院治疗的老年患者,随机分为盐酸莫西沙星组（96例）和头孢曲松钠组（96例）,分别予以盐酸莫西沙星、头孢曲松钠治疗10~14 d,分别在治疗前后检测12导联同步心电图、血常规和生化全套.结果 盐酸莫西沙星组治疗后QTc 较头孢曲松钠组延长,差异有统计学意义（P〈0.05）.结论 盐酸莫西沙星能延长老年患者QTc间期,存在致心律失常的潜在可能性,治疗期间应注意复查心电图.

Objective To investigate the effects of moxifloxacin hydrochloride on corrected QT interval （QTc） in elderly patients with pulmonary infection. Methods A total of 192 elderly patients with pulmonary infection in our hospital were randomly divided into two groups, moxifloxacin hydrochloride group （96 cases） and ceftriaxone sodium group （96 cases）, who were separately treated with the corresponding drugs for 10-14 days. Carry out 12-lead simultaneous ECG, blood routine examination and biochemistry complete set before and after the treatment. Results Comparing with ceftriaxone sodium group, the QTc of moxifloxacin hydrochloride group was prolonged after the treatment, and the difference was statistically significant （P 〈 0. 05 ）. Conclusion Moxifloxacin hydrochloride could prolong QTc interval in elderly patients, which may result in arrhythmia. ECG reexamination should be taken during the treatment.