血府逐瘀汤治疗慢性乙型肝炎肝纤维化患者41例

Observation on Effect of Xuefu Zhuyu Decoction for Treating 41 Cases of Hepatitis B Caused Liver Fibrosis

目的观察血府逐瘀汤治疗慢性乙型肝炎肝纤维化患者的疗效。方法将82例慢性乙型肝炎肝纤维化患者随机均分为观察组和对照组,两组患者均给予干扰素抗病毒治疗,观察组患者加用口服血府逐瘀汤治疗,比较两组患者治疗前后血清肝纤维化指标改善情况和治疗后的临床效果。结果观察组患者治疗后Ⅲ型前胶原(PCⅢ)、透明质酸(HA)及层黏连蛋白(LN)水平较治疗前均明显下降(P<0.05),且均低于对照组(P<0.05);观察组治疗后门静脉血流量小于治疗前和对照组,平均血流速度大于治疗前和对照组(P<0.05),门静脉主干内径与治疗前比较无明显差异(P>0.05)。观察组患者治疗总有效率为87.80%,明显高于对照组的65.85%(P<0.05)。结论血府逐瘀汤联合干扰素治疗慢性乙型肝炎肝纤维化,可提高门静脉平均血流速度,降低门静脉血流量,降低Ⅲ型前胶元、透明质酸及层黏连蛋白等血清肝纤维化指标。

Objective To observe the effect of Xuefu Zhuyu Decoction for treating liver fibrosis caused by hepatitis B. Methods 82 cases of chronic hepatitis B caused liver fibrosis were collected as the research subjects and were randomLy divided into the observa- tion group and the control group. All the patients in the two groups were given the interferon antiviral therapy. The patients of the ob- servation group were added with oral Xuefu Zhuyu Decoction. Then the improvement of serum indexes of liver fibrosis and the curative effects after treatment were compared between the two groups. Results The serum procollagen HI （PC Ill ）, hyaluronan（HA） and laminin （LN） levels of the observation group after treatment were significantly decreased than before treatment,and lower than those of the con- trol group,the differences had statistical significance（ P 〈 0.05）. The portal venous flow volume of the observation group after treatment was less than that before treatment and of the control group,the mean portal venous flow velocity after treatment was higher than that before treatment and of the control group,the differences had statistical significance （P 〈 0. 05）. The main portal vein diameter of the observation group after treatment had no obvious difference compared with before treatment without statistical significance（P 〉 0.05）; the portal venous flow volume of the observation group after treatment was less than that of the control group and the mean portal ve- nous flow velocity after treatment was higher than that of the control group,the differences showing statistical significance （P 〈 0.05 ）. The total effective rate of the observation group was 87.80% ,which was significantly higher than 65.85% of the control group,the dif- ference had statistical significance（ P 〈 0. 05）. Conclusion Xuefu Zhuyu Decoction combined with interferon for treating hepatitis B caused liver fibrosis could improve the mean portal venous flow velocity, reduce the portal venous flow volume and the serum liver fi- brosis indexes of PC III, HA and LN.