尼可地尔联合倍他乐克治疗不稳定型心绞痛临床效果观察

Observation of the clinical efficacy of nicorandil and betaloc in the treatment of unstable angina

目的观察尼可地尔联合倍他乐克治疗不稳定型心绞痛的临床效果。方法将武汉大学人民医院100例不稳定型心绞痛患者完全随机分为倍他乐克组（48例）和联合治疗组（52例）。在原有疾病治疗基础上，倍他乐克组加用倍他乐克每日25～100mg，联合治疗组给予倍他乐克每日25—100mg加尼可地尔5mg每日3次口服治疗，共4周，比较2组临床症状缓解情况及心电图ST—T的变化。结果临床症状疗效：倍他乐克组显效率为77．1％（37／48），总有效率为87．5％（42／48）；联合治疗组显效率为84．6％（44／52），总有效率为96．2％（50／52）。倍他乐克组显效率、总有效率高于联合治疗组，差异有统计学意义（均P〈0．05）。心电图疗效：倍他乐克组显效率为66．7％（32／48），总有效率为81．2％（39／48）；联合治疗组显效率为78．8％（41／52），总有效率为90．3％（47／52）。倍他乐克组显效率、总有效率高于联合治疗组（P〈0．05）。结论尼可地尔联合倍他乐克治疗不稳定型心绞痛疗效确切。

Objective To estimate the clinical efficacy of nieorandil and betaloe in the treatment of unstable angina. Methods Totally 100 patients of unstable angina were randomly divided into the basic treatment group （48 eases） and nieorandil group （52 eases）. Based on the treatment of primary disease, patients were divided into betaloe group and nieorandil group. Clinical symptoms alleviation and electrocardiogram changes of ST-T segment were compared. Results The efficacy of clinical symptoms： the effective rates and total effective rates of basic treatment group were 77.1% and 87.5% ; Nicorandil group were 84.6% and 96.2%. The effective rates and total effective rates of nicorandil group were higher than those of the basic treatment group （P 〈 0.05 ）. The efficacy of electrocardiogram： the effective rates and total effective rates of basic treatment group were 66.7% and 81.2% ; nicorandil group were 78.8% and 90.3%. The effective rates and total effective rates of nicorandil group were higher than those of the basic treatment group （P 〈 0.05 ）. Conclusion The efficacy of nicorandil and betaloc in the treatment of unstable angina is good.