银杏酮酯滴丸治疗冠心病PCI术后再发心绞痛的临床观察

Effects of Yinxing Tongzhi guttate pills in the treatment of angina pectoris after percutaneous coronary intervention

目的:观察银杏酮酯滴丸治疗冠心病经皮冠状动脉介入治疗(Percutaneous coronary intervention,PCI)术后再发心绞痛的疗效以及对血脂水平的影响。方法:选择经我院及外院行冠心病PCI术后再发心绞痛住院患者74例,随机分为常规治疗组(对照组)和在常规治疗上加银杏酮酯滴丸治疗(观察组),疗程2w,比较两组治疗后的临床表现、体征、心电图的改善程度及血脂水平的变化。结果:治疗后治疗组与对照组的总有效率分别为94.59%、75.68%(P<0.05);两组治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-c)水平较治疗前下降(P<0.05),治疗组上述指标较对照组下降更明显(P<0.05)。治疗组在用药过程中未见明显不良反应。结论:银杏酮酯滴丸能显著改善冠心病PCI术后再发心绞痛症状,调整血脂,减轻炎症反应,是辅助治疗冠心病PCI术后再发心绞痛的一种安全有效的方法。

Objective： To observe the effect of Yinxing Tongzhi guttate pills（YTP） in blood lipid and clinical effects on patients with angina pectoris （AP） after PCI. Methods： 74 patients with AP after PCI were randomly divided into YTP treatment group （n= 37） and normal treatment group （n=37）. Patients in both groups were treated with aspirin （50 mg, po, qd）, clopidogrel （75 mg, po, biw）, nitrate esters （Nitroglycerin, 0. 3 mg, prn）, tow molecular weight heparin （2050AxaIU, iv, prn）, β-blockers （rod）, calcium channel antagonist （rod） and statins （rod） etc. Patients in the treatment group were given Yinxing Tongzhi guttate pills （40 mg, rid） in addition. After 2 weeks, the improvement of symptom and the changes of blood lipid were observed. Results： After 2 weeks of treatment the total effective rate of the two groups was respectively 94.59% （YTP treatment group） and 75.68% （normal treatment group）, the YTP treatment group was better than the normal treatment group obviously （P〈0.05）. The serum levels of TC, TG and LDL-C were significantly decreased in both of the two groups（P〈0.05） as compared to them before treatment, but more obviously in the YTP treatment group, compared with normal treatment group （P〈0. 05）. During the treatment, there was no obvious adverse reaction in the treatment group. Conclusion： Yinxing Tongzhi guttate pills can improve the clinical symptom of patients with AP after PCI, inhibit the inflammatory response, and adjust blood lipid.