苯海索对蛛网膜下腔出血后脑皮质单胺递质的影响

Effects of Trihexyphenidyl on Monoamine Neurotransmitters in Cerebral Cortex after Subarachnoid Hemorrhage

目的 探讨苯海索 (THP)对蛛网膜下腔出血 (SAH)后脑皮质内单胺递质水平的影响。方法 采用大鼠SAH动物模型 ,用荧光分光光度法检测了去甲肾上腺素 (NE)、多巴胺 (DA)、5 羟色胺 (5 HT)和 5 羟吲哚乙酸(5 HIAA)的水平。结果 SAH后脑皮质内NE(P <0 .0 1)、5 HT(P <0 .0 1)、5 HIAA(P <0 .0 1)的水平均显著升高 ,DA有升高趋势 ,但无统计学意义 ;THP可明显抑制SAH后脑皮质内NE、5 HT、5 HIAA的升高。结论 SAH可引起脑皮质内NE、5 HT、5 HIAA水平的明显升高 ,THP能有效改善SAH后脑皮质NE和 5

Purpose To study the effects of trihexyphenidyl (THP) on levels of monoamine neurotransmitters in the cerebral cortex after subarachnoid hemorrhage (SAH). Methods SAH model of rats were used,the levels of norepinephrine (NE),dopamine(DA),5 hydroxytrypatamine (5?HT) and hydroxyindoleacetic acid (5?HIAA) were measured by flurospectrophotometry. Results There was an extensive increase in levels of NE ( P < 0.01 ),5?HT ( P <0.01) and 5?HIAA ( P <0.01) in the cerebral cortex after SAH,DA had a tendency to increase without significance.The increase in levels of NE ( P < 0.01 ),5?HT ( P <0.01) and 5?HIAA ( P <0.05) in the cerebral cortex after SAH could be effectively inhibited by THP. Conclusions There will be a remarkable increase in levels of NE,5?HT and 5?HIAA in the cerebral cortex after SAH,THP could significantly ameliorate the metabolic disorder of NE and 5?HT after SAH.